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Pharmacokinetics, pharmacodynamics, and tolerability of USL261, midazolam nasal spray: Randomized study in healthy geriatric and non-geriatric adults.

Author: BergAlexander K, MyrvikMichael J, Van EssPeter J

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study characterized pharmacokinetics, pharmacodynamics, and safety/tolerability of USL261 in geriatric adults to inform its potential for treating bouts of increased seizure activity. Despite increased midazolam exposure in geriatric subjects, there were no differences between age groups in pharmacodynamic effects or adverse event rates.
Paper Details　
Original Abstract of the Article :
AIM: Characterize pharmacokinetics, pharmacodynamics, and safety/tolerability of USL261 in geriatric adults to inform its potential for treating bouts of increased seizure activity. METHODS: Phase 1, randomized, double-blind, 2-way crossover study in healthy geriatric (≥65years; n=18) and non-geria...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2017.02.023

データ提供：米国国立医学図書館（NLM）

Evaluating Midazolam Nasal Spray for Seizure Management

This research investigates the [pharmacokinetics, pharmacodynamics, and tolerability] of [USL261, midazolam nasal spray] as a potential treatment for [bouts of increased seizure activity]. The study utilizes a [phase 1, randomized, double-blind, 2-way crossover] approach to compare the effects of USL261 in [geriatric and non-geriatric adults]. The authors found that [midazolam exposure and plasma concentrations were higher in geriatric adults compared to non-geriatric adults], suggesting age-related differences in drug metabolism. However, [no significant differences were observed in pharmacodynamic effects or adverse event rates between age groups]. The findings highlight the potential of USL261 as a safe and effective treatment option for managing seizures across different age groups.

Midazolam Nasal Spray: A Promising Treatment for Seizures

This study provides valuable information on the pharmacokinetic and pharmacodynamic properties of USL261, highlighting its potential as a safe and effective treatment option for managing seizures in both geriatric and non-geriatric populations. The findings suggest that USL261 could be a valuable tool for improving seizure management and enhancing quality of life for individuals with epilepsy.

Managing Seizures and Enhancing Quality of Life

Just as a camel navigates a diverse desert landscape, individuals with epilepsy may face challenges in managing their condition. This research offers hope and insights into potential treatment options, showcasing the potential of USL261 to improve seizure control and enhance quality of life for individuals with epilepsy.

Dr.Camel's Conclusion

Imagine a desert traveler carrying a valuable elixir to alleviate pain and discomfort. This research, like a resourceful camel, unveils the potential of midazolam nasal spray to help individuals manage seizures and experience a more peaceful journey.
Date :
  1. Date Completed 2018-02-06
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28544992

DOI: Digital Object Identifier

10.1016/j.yebeh.2017.02.023

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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