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Indirect comparisons of the efficacy of biological agents in patients with active ankylosing spondylitis: a systematic review and meta-analysis.

Author: ErwinPatricia J, KosterMatthew J, UngprasertPatompong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study compares the effectiveness of different biological agents for treating ankylosing spondylitis (AS) in patients who have failed or are intolerant to NSAIDs. The study finds no significant difference in effectiveness between older TNF inhibitors, secukinumab, certolizumab, and tofacitinib.
Paper Details　
Original Abstract of the Article :
Patients with ankylosing (AS) often do not have a satisfactory response to, or could not tolerate, non-steroidal anti-inflammatory drugs (NSAIDs). Several biologic agents are available for such patients. However, the comparative efficacy of these treatments remains unknown as head-to-head randomized...See full text at original site
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引用元：
https://doi.org/10.1007/s10067-017-3693-7

データ提供：米国国立医学図書館（NLM）

Ankylosing Spondylitis: Comparing Biologic Treatments

The field of rheumatology is constantly seeking better treatments for inflammatory conditions like ankylosing spondylitis. This study delves into the efficacy of various biologic agents for managing ankylosing spondylitis (AS) in patients who haven't responded well to traditional treatments. The researchers conducted a systematic review and meta-analysis of clinical trials to compare the effectiveness of different biologic therapies for AS.

Finding the Right Oasis in the Desert of AS

The study revealed that several biologic agents are available for treating AS, but head-to-head comparisons between these options are limited. The researchers analyzed the pooled data from clinical trials to indirectly compare the effectiveness of various biologic treatments. The results showed no significant differences in efficacy between the tested biologic agents in achieving a 20% improvement in AS symptoms. This study provides valuable information for clinicians to guide treatment decisions for patients with AS, helping them navigate the desert of available treatment options.

Choosing the Best Treatment Path

This study provides valuable insights into the effectiveness of various biologic agents for managing ankylosing spondylitis. It highlights the need for further research to directly compare the efficacy of different treatments and to identify the optimal approach for each individual patient. Like a caravan traversing the desert, patients with AS need careful guidance and tailored treatment plans to ensure their best possible outcomes.

Dr.Camel's Conclusion

The search for the most effective biologic treatment for ankylosing spondylitis continues. This study provides valuable information for clinicians and patients, helping them navigate the diverse landscape of available options. Further research is needed to gain a deeper understanding of the long-term benefits and risks of these treatments. Just as a wise camel chooses its path carefully through the desert, finding the right treatment for AS requires a thoughtful and collaborative approach.

Date :
  1. Date Completed 2018-03-29
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28551823

DOI: Digital Object Identifier

10.1007/s10067-017-3693-7

SNS
PICO Info
in preparation
Languages

English

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