Paper Details

  1. Home
  2. Paper Details

Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine.

Author: AhsanMd Kaimul, AmeenNadia A, ArthurDavid, HannigGerhard, KesslerMarco M, LindeCristina I, Silos-SantiagoInmaculada, SolingaRobert M, TchernychevBoris

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the mechanisms underlying the action of linaclotide, a GC-C agonist peptide used for treating Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation. The study demonstrated that linaclotide activates the GC-C/cGMP/PKG-II/CFTR pathway, leading to increased intestinal fluid secretion. Linaclotide-dependent CFTR activation and recruitment/trafficking from subapical vesicles to the cell surface are crucial steps in this process.
Paper Details　
Original Abstract of the Article :
The transmembrane receptor guanylyl cyclase-C (GC-C), expressed on enterocytes along the intestine, is the molecular target of the GC-C agonist peptide linaclotide, an FDA-approved drug for treatment of adult patients with Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipatio...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471438/

データ提供：米国国立医学図書館（NLM）

Linaclotide and CFTR Trafficking in the Intestine

This research delves into the complex world of intestinal function, focusing on the role of linaclotide, a drug used to treat constipation. It's like examining the intricate network of canals that transport water through a desert oasis. The researchers explored how linaclotide, a guanylate cyclase-C (GC-C) agonist, activates the GC-C/cGMP/protein kinase-II (PKG-II) signaling pathway, which leads to the translocation of cystic fibrosis transmembrane conductance regulator (CFTR) to the cell surface in the intestine. This process is like opening a valve in the oasis's irrigation system, allowing water to flow freely. They found that linaclotide treatment increased fluid secretion and CFTR cell surface levels, suggesting that this pathway is crucial for intestinal fluid secretion.

Understanding the Mechanism of Action

This research provides valuable insights into the mechanism of action of linaclotide, a drug used to treat constipation. It's like unraveling the mysteries of an oasis's irrigation system, revealing the intricate network of pathways that regulate water flow.

Optimizing Intestinal Function

This research has important implications for understanding and treating intestinal disorders. It's like discovering new ways to maintain the health and function of a desert oasis, ensuring its continued well-being. By understanding the role of linaclotide and the GC-C/cGMP/PKG-II signaling pathway, we can develop more effective therapies for intestinal conditions.

Dr. Camel's Conclusion

This research explores the intricate world of intestinal function, revealing how linaclotide impacts the delicate balance of water flow in the body. It's like observing the rhythmic flow of water through a desert oasis's irrigation system, a testament to the complexity and wonder of the human body. This research is a valuable contribution to our understanding of intestinal disorders and their treatment.

Date :
  1. Date Completed 2018-03-26
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

28592587

DOI: Digital Object Identifier

PMC5471438

Related Literature

Article Analysis
・Effects of linaclotide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.