The presence of minocycline in the tear film of normal horses following oral administration and its anticollagenase activity.

Author: GibsonDaniel James, JeongSun Young, MonkCaroline S, PlummerCaryn E

Paper Details 
Original Abstract of the Article :
Tetracyclines have activity against matrix metalloproteinases (MMP). Oral medications with effects on the ocular surface are of interest in patients where repeated topical dosing is limited. The aim of this study was to characterize the concentration of minocycline in the tears of normal horses afte...See full text at original site
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引用元:
https://doi.org/10.1111/vop.12479

データ提供:米国国立医学図書館(NLM)

Minocycline in Tears: A Potential Treatment for Ocular Conditions

This research explores the potential of minocycline, a tetracycline antibiotic, for treating ocular conditions. The study investigates the presence of minocycline in the tear film of horses after oral administration and its potential anticollagenase activity. The researchers aim to determine if minocycline can reach therapeutic levels in the tear film and potentially inhibit matrix metalloproteinases (MMPs), enzymes involved in various ocular diseases.

Oral Minocycline Shows Promise for Ocular Applications

The study findings indicate that minocycline can be detected in the tear film of horses after oral administration, suggesting its potential for topical application. Additionally, the study found that minocycline exhibits anticollagenase activity, potentially making it a valuable therapeutic agent for ocular conditions characterized by excessive MMP activity.

Navigating Ocular Health with Innovative Solutions

Think of it this way: Imagine a camel caravan traveling through a desert with harsh winds and sandstorms. Protecting their eyes is crucial for their safe journey. Similarly, maintaining healthy eyes requires addressing potential threats, such as excessive MMP activity. This research explores the potential of oral minocycline to provide a protective shield for the eyes, offering a novel approach to treating ocular conditions.

Dr. Camel's Conclusion

This study suggests that oral minocycline may offer a valuable alternative to topical medications for treating certain ocular conditions. The presence of minocycline in the tear film and its anticollagenase activity highlight its potential for managing ocular diseases characterized by excessive MMP activity. This research opens up exciting possibilities for developing innovative treatment approaches for maintaining healthy vision.

Date :
  1. Date Completed 2018-06-26
  2. Date Revised 2018-06-26
Further Info :

Pubmed ID

28598549

DOI: Digital Object Identifier

10.1111/vop.12479

Related Literature

SNS
PICO Info
in preparation
Languages

English

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