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Genetically determined variability in acetylation and oxidation. Therapeutic implications.

Author: ClarkD W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Acetylation and oxidation polymorphism significantly influence drug metabolism, leading to variations in therapeutic response and risk of adverse effects. Phenotyping for acetylator status is recommended in some cases, particularly when drug interactions are suspected or when considering hydralazine therapy due to the risk of systemic lupus erythematosus.
Paper Details　
Original Abstract of the Article :
The clinical significance of two separate genetic polymorphisms which alter drug metabolism, acetylation and oxidation is discussed, and methods of phenotyping for both acetylator and polymorphic oxidation status are reviewed. Particular reference is made to the dapsone method, which provides a simp...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.2165/00003495-198529040-00003

データ提供：米国国立医学図書館（NLM）

Genetic Variability and Drug Metabolism: Understanding the Importance of Individual Differences

Drug metabolism, the process by which our bodies break down and eliminate medications, varies significantly from person to person. This research explores the clinical significance of two genetic polymorphisms that influence drug metabolism: acetylation and oxidation. The authors discuss the importance of phenotyping, or determining an individual's metabolic profile, to optimize drug treatment and minimize adverse reactions. It’s like understanding the different types of desert terrain and their unique challenges, allowing travelers to navigate the landscape more safely.

Personalized Medicine: Tailoring Treatments to Individual Needs

This research underscores the importance of personalized medicine, taking into account individual genetic variations to optimize drug treatment. Phenotyping for acetylation and oxidation status can help to predict drug response and minimize adverse reactions.

A More Precise Approach to Drug Therapy

By understanding the genetic variability in drug metabolism, healthcare professionals can develop more precise treatment plans, tailoring dosages and medications to the individual's specific metabolic profile.

Dr. Camel's Conclusion

Drug metabolism is a complex process that varies greatly between individuals, like the diverse landscapes of a desert. This research highlights the importance of phenotyping for acetylation and oxidation to optimize drug treatment and minimize adverse reactions. Remember, just as a desert traveler must adapt to changing terrain, we must tailor our healthcare practices to accommodate individual differences.

Date :
  1. Date Completed 1985-07-11
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

2859977

DOI: Digital Object Identifier

10.2165/00003495-198529040-00003

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English

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