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Chronic pramipexole treatment induces compulsive behavior in rats with 6-OHDA lesions of the substantia nigra and ventral tegmental area.
Author: ChassainC, DardouD, DurifF, ReyrolleL
Original Abstract of the Article :
Dopamine replacement therapy (DRT) reduces motor symptoms in Parkinson's disease (PD), but also induces impulsive-compulsive behavior (ICB) in up to 25% of PD patients. These non-motor side effects of DRT generally follow a gradual transition from impulsive to compulsive-like-i.e. repetitive, compel...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1016/j.bbr.2017.06.016
データ提供：米国国立医学図書館（NLM）
Pramipexole: A Double-Edged Sword in Parkinson's Disease
This research explores the potential development of compulsive behavior in rats with Parkinson's disease (PD) treated with chronic pramipexole, a dopamine replacement therapy (DRT). The study utilizes a 6-hydroxydopamine (6-OHDA) lesion model to mimic PD and investigates the effect of pramipexole on compulsive lever-pressing behavior. The findings reveal that chronic pramipexole treatment can induce compulsive behavior in rats with PD, highlighting the potential for non-motor side effects associated with DRT. The research also identifies potential brain regions involved in the development of this compulsive behavior.
Understanding the Side Effects of Dopamine Replacement Therapy
This study provides valuable insights into the potential for non-motor side effects associated with dopamine replacement therapy in Parkinson's disease. The findings suggest that chronic pramipexole treatment can induce compulsive behaviors, highlighting the need for careful monitoring and management of these side effects in patients receiving DRT. The study's identification of brain regions involved in compulsive behavior could lead to the development of new strategies for preventing or mitigating these side effects.
The Challenges of Managing Parkinson's Disease
This research underscores the complex nature of managing Parkinson's disease. While dopamine replacement therapy can significantly improve motor symptoms, it can also lead to undesirable side effects such as compulsive behaviors. This study emphasizes the need for a comprehensive approach to managing PD, balancing the potential benefits of DRT with the risks of adverse effects.
Dr.Camel's Conclusion
Just as a camel can be both a valuable asset and a potential burden in a desert journey, dopamine replacement therapy in Parkinson's disease can be a double-edged sword. This study, like a seasoned desert guide, unveils the potential for compulsive behavior associated with pramipexole treatment, reminding us that careful monitoring and management are crucial in navigating the complex landscape of Parkinson's disease.
Date :
- Date Completed 2017-12-12
- Date Revised 2018-12-02
Further Info :
Related Literature
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