Paper Details

  1. Home
  2. Paper Details

More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.

Author: , BroekmanMark M T J, CoenenMarieke J H, DerijksLuc J J, GuchelaarHenk-Jan, HooymansPiet M, KlungelOlaf H, SchefferHans, VerbeekAndre L M, WantenGeert J A, WongDennis R, de JongDirk J, van MarrewijkCorine J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared azathioprine (AZA) and mercaptopurine (MP) in thiopurine-naive patients with inflammatory bowel disease (IBD). The study aimed to determine the frequency of side effects and efficacy of both medications.
Paper Details　
Original Abstract of the Article :
There are substantial global differences in the preference for mercaptopurine (MP) or its prodrug azathioprine (AZA) as first-choice thiopurine to treat inflammatory bowel diseases. Studies comparing both agents are scarce. Our aim was to compare AZA and MP in thiopurine-naive patients with inflamma...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598908/

データ提供：米国国立医学図書館（NLM）

Comparing Mercaptopurine and Azathioprine for Inflammatory Bowel Disease

This research delves into the realm of [gastroenterology and pharmacotherapy], focusing on the comparison of mercaptopurine (MP) and azathioprine (AZA) for the treatment of inflammatory bowel diseases (IBD). The study, using a [retrospective cohort analysis], aimed to compare the frequency of side effects and efficacy of MP and AZA in thiopurine-naive patients with IBD. The researchers found that MP was associated with a higher frequency of side effects than AZA, likely due to the relatively higher dosing of MP.

Dose-Dependent Side Effects of Thiopurines

The study demonstrated that the frequency of side effects with MP and AZA is dose-dependent. This finding highlights the importance of careful monitoring and dose adjustment for these medications. Clinicians should be aware of the potential for higher side effects with MP, especially when higher doses are required. This research provides valuable information for guiding treatment decisions and minimizing the risk of adverse effects.

Optimizing Treatment for Inflammatory Bowel Disease

This research contributes to the ongoing effort to optimize treatment for IBD. The study's findings highlight the importance of carefully considering the choice of thiopurine agent and dose based on individual patient factors and the potential for side effects. This research underscores the need for continued research to understand the optimal use of these medications in IBD.

Dr.Camel's Conclusion

Like a camel choosing the best path through a desert landscape, clinicians must navigate the complex world of IBD treatment options. This research sheds light on the potential for dose-dependent side effects with thiopurines, emphasizing the importance of careful dose adjustment and monitoring. This research, like a map guiding us through the vast desert of IBD, offers valuable insights for optimizing patient care and minimizing the risk of adverse effects.

Date :
  1. Date Completed 2018-05-31
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28644183

DOI: Digital Object Identifier

PMC5598908

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.