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Biosynthesis of (S)-naproxen starch ester by Carica papaya lipase in intermittent opening reaction mode.

Author: LiQuan-Hui, SunLi-Rui, WangYan, XiaChun-Gu, XinJia Ying

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the synthesis of a slow-release, optically pure (S)-naproxen starch ester using lipase-catalyzed trans-esterification. The resulting S-naproxen starch showed emulsifying and slow-release properties, which could be beneficial for improving the efficacy and reducing the side effects of naproxen.
Paper Details　
Original Abstract of the Article :
Inorder to brought S-naproxen into small intestine, an optically pure (S)-naproxen starch ester was produced by lipase through enantio-selective trans-esterification of racemic naproxen methyl ester with pretreatment starch in solvent system. With carefully selection of the reaction medium (isooctan...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28655691

データ提供：米国国立医学図書館（NLM）

(S)-Naproxen Starch Ester: A Desert Oasis of Drug Delivery

Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), can be effective in reducing pain and inflammation, but it can also have undesirable side effects. This research explores the synthesis of (S)-naproxen starch ester, a novel drug delivery system designed to improve the efficacy and reduce the side effects of naproxen.

(S)-Naproxen Starch Ester: A Desert Oasis of Innovation

The study successfully synthesized (S)-naproxen starch ester using lipase-catalyzed transesterification. This novel drug delivery system is designed to provide slow release of naproxen, potentially improving its effectiveness and reducing its side effects.

(S)-Naproxen Starch Ester: A Desert Oasis of Drug Development

This research demonstrates the potential of using biocatalysts, like lipases, to create novel drug delivery systems that can improve the efficacy and safety of existing medications. It highlights the importance of exploring new approaches to drug development, particularly those focused on enhancing drug delivery and minimizing side effects.

Dr. Camel's Conclusion

This study highlights the innovative potential of (S)-naproxen starch ester as a novel drug delivery system for naproxen. It underscores the importance of exploring new approaches to drug delivery, particularly those focused on improving efficacy and reducing side effects.
Date :
  1. Date Completed 2019-07-09
  2. Date Revised 2019-07-09
Further Info :

Pubmed ID

28655691

DOI: Digital Object Identifier

28655691

Related Literature

Article Analysis
・Side Effects of naproxen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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