Quazepam and temazepam: effects of short- and intermediate-term use and withdrawal.

Author: BixlerE O, JacobyJ A, KalesA, KalesJ D, SoldatosC R, Vela-BuenoA

Paper Details 
Original Abstract of the Article :
Two benzodiazepine hypnotics, one with an intermediate elimination t1/2 (temazepam, 15 mg) and the other with a long t1/2 (quazepam, 15 mg), were evaluated in 22- night sleep laboratory studies. The effectiveness and side effects of these benzodiazepines were assessed during short- and intermediate ...See full text at original site
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引用元:
https://doi.org/10.1038/clpt.1986.51

データ提供:米国国立医学図書館(NLM)

Navigating the Terrain of Benzodiazepine Use

In the realm of [sleep disorders], [benzodiazepines] are a class of medications commonly used to treat [insomnia]. This study explores the [short- and intermediate-term effects] of two benzodiazepines, [temazepam] and [quazepam], on [sleep quality and potential side effects]. The research involved a [sleep laboratory study] where participants received either temazepam or quazepam for a period of several weeks. The findings indicate that both medications were [effective in improving sleep] initially, but [tolerance] developed more rapidly with temazepam. While temazepam was well-tolerated, [quazepam] was associated with [daytime sleepiness]. The study also investigated [withdrawal effects] and found that temazepam was associated with [rebound insomnia] after abrupt discontinuation, while quazepam had [carryover effectiveness]. This research is like a desert explorer venturing into the complexities of medication effects, carefully navigating the potential benefits and risks.

Understanding the Trade-offs of Benzodiazepine Use

This study highlights the importance of [carefully considering] the potential [benefits and risks] associated with benzodiazepine use. The research suggests that [long-acting benzodiazepines like quazepam] may offer a more [gradual withdrawal] and [less severe rebound insomnia] compared to [short-acting benzodiazepines like temazepam]. Just as a camel carefully manages its water consumption in the desert, we must approach benzodiazepine use with a balanced understanding of its potential effects.

A Reminder to Seek Professional Guidance

This research underscores the importance of [consulting with a healthcare professional] before taking any sleep medication. The study's findings emphasize the need for [individualized treatment plans] and careful monitoring to ensure safe and effective use of benzodiazepines. Just as a camel relies on its innate wisdom to navigate the desert, we must trust in the expertise of medical professionals to guide us through the complexities of sleep disorders.

Dr.Camel's Conclusion

This study provides valuable insights into the complex effects of benzodiazepines, reminding us that medications can offer both benefits and risks. As a wise camel, I encourage everyone to approach sleep medications with caution, seeking professional guidance and understanding the potential consequences of long-term use.
Date :
  1. Date Completed 1986-04-10
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2868823

DOI: Digital Object Identifier

10.1038/clpt.1986.51

Related Literature

SNS
PICO Info
in preparation
Languages

English

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