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The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions.
Author: IllingPatricia T, McCluskeyJames, PurcellAnthony W
Original Abstract of the Article :
Genetic polymorphism in the genes encoding the human leukocyte antigen (HLA) molecules enables presentation of a wide range peptide ligands thus maximising immune surveillance of pathogens. A consequence of the diversification of the HLA Ag-binding pocket is the enhanced opportunity for off-target b...See full text at original site
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引用元:
https://doi.org/10.1007/s00251-017-1007-5
データ提供:米国国立医学図書館(NLM)
The Hidden World of HLA Genes and Drug Reactions
The intricate dance of our immune system, a complex interplay of proteins, genes, and cells, is a fascinating aspect of human biology. HLA genes, the gatekeepers of our immune system, are particularly important in understanding the intricate workings of our bodies' defense mechanisms. These genes, like ancient sentinels guarding a desert oasis, determine the proteins that identify and present foreign invaders like viruses and bacteria to our immune system.
This research dives deep into the fascinating world of pharmacogenomics, exploring the often-overlooked role of HLA genes in drug reactions. The authors propose that these genes, like intricate sand dunes, can potentially bind to small drug molecules, triggering immune responses. This unexpected interaction, like a hidden oasis in the desert, can lead to adverse drug reactions. The study’s findings illustrate the importance of understanding these interactions, as they can be crucial in preventing adverse drug reactions.
Unveiling the Mysteries of Drug Reactions
This research sheds light on the complex interactions between HLA genes and medications, an area that has been a puzzle for many years. The study's findings provide valuable insights into the mechanisms behind certain drug reactions, like deciphering the secrets hidden beneath the desert sands. Understanding these mechanisms is crucial for developing safer and more effective medications.
The Importance of Genetic Testing for Personalized Medicine
The study underscores the importance of personalized medicine, tailoring treatment plans to individual patients. Understanding a patient's HLA genotype, like analyzing the intricate patterns of desert sand, can help predict potential drug reactions and optimize treatment outcomes.
Dr.Camel's Conclusion
This research delves into the hidden complexities of pharmacogenomics, uncovering the intricate interplay between our genes and our response to medications. Understanding these interactions, like mapping the hidden oasis in the desert, is crucial for developing safer and more effective therapies.
Date :
- Date Completed 2017-09-29
- Date Revised 2022-08-01
Further Info :
Related Literature
English
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