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Long-acting formulation leading to severe long-term adverse effects: a case report of fluphenazine and persistent extrapyramidal symptoms.

Author: MatsunagaH, MitsuiY, OmiT

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Long-acting formulations of fluphenazine decanoate may lead to severe persistent extrapyramidal symptoms. Antiparkinsonian drug therapy with bromocriptine may be a possible option for preventing fluphenazine-induced side effects.
Paper Details　
Original Abstract of the Article :
WHAT IS KNOWN AND OBJECTIVE: Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION: We present a patient with schizophren...See full text at original site
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引用元：
https://doi.org/10.1111/jcpt.12589

データ提供：米国国立医学図書館（NLM）

Fluphenazine: A Double-Edged Sword

Fluphenazine, a long-acting medication used to treat schizophrenia, is a double-edged sword. While it can provide much-needed relief for patients struggling with this debilitating illness, it can also have serious side effects, including persistent extrapyramidal symptoms (EPS) - movement disorders.

A Case of Fluphenazine-Induced EPS

This case report highlights the potential dangers of long-acting fluphenazine. The patient, diagnosed with schizophrenia, developed severe and persistent EPS requiring tracheostomy and long-term rehabilitation after receiving long-acting fluphenazine decanoate injections. The EPS improved with declining fluphenazine concentration and treatment with the antiparkinsonian drug bromocriptine.

Navigating the Side Effects

This case report underscores the importance of careful monitoring and management of long-acting medications, particularly those with a risk of severe side effects. For patients taking fluphenazine, vigilant attention to symptoms and prompt intervention, such as antiparkinsonian therapy, are essential in mitigating potential risks and ensuring patient safety.

Dr. Camel's Conclusion

This research, like a desert oasis providing respite from the harsh sun, sheds light on the potential dangers of long-acting fluphenazine. The case report emphasizes the importance of balancing the benefits of medication with the potential risks. Just as a traveler must carefully navigate the desert to avoid dangers, healthcare professionals must carefully manage medication to ensure patient safety and well-being.
Date :
  1. Date Completed 2018-08-02
  2. Date Revised 2018-08-02
Further Info :

Pubmed ID

28718220

DOI: Digital Object Identifier

10.1111/jcpt.12589

Related Literature

Article Analysis
・Side Effects of fluphenazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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