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Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.

Author: CogoElise, D'SouzaJennifer, FinkelsteinYaron, HemmelgarnBrenda R, HuttonBrian, KealeyRyan, MacDonaldHeather, ReynenEmily, RiosPatricia, SoobiahCharlene, StrausSharon E, ThavornKednapa, TriccoAndrea C, VeronikiAreti Angeliki, YazdiFatemeh

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Valproate alone or combined with another AED is associated with the greatest odds of adverse neurodevelopmental outcomes compared with control.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Compare the safety of antiepileptic drugs (AEDs) on neurodevelopment of infants/children exposed in utero or during breast feeding. DESIGN AND SETTING: Systematic review and Bayesian random-effects network meta-analysis (NMA). MEDLINE, EMBASE and the Cochrane Central Register of Control...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642793/

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Epilepsy: A Guide to Antiepileptic Drug Safety

Epilepsy, a neurological disorder characterized by recurrent seizures, can be a challenging condition to manage. This systematic review and network meta-analysis embarks on a journey through the vast desert of antiepileptic drug (AED) research, seeking to understand the safety of these medications for neurological development in children exposed during pregnancy or breastfeeding. Researchers, like explorers charting a treacherous landscape, meticulously analyzed data from 29 cohort studies, comparing the effects of various AEDs on cognitive development, autism, and other neurodevelopmental outcomes.

A Beacon of Hope: Navigating the Landscape of AED Safety

This comprehensive analysis provides valuable guidance for clinicians and families navigating the complex landscape of AED treatment for epilepsy. The findings highlight the importance of tailoring treatment decisions to individual needs, particularly for pregnant women, to minimize potential neurodevelopmental risks. Valproate, for example, emerged as a drug associated with significantly increased odds of adverse neurodevelopmental outcomes.

The Desert Oasis of Safe Treatment: Protecting Our Children's Neurological Development

Epilepsy, like a vast desert, can be a challenging terrain to navigate, especially for children. This research offers a beacon of hope, providing valuable insights into the safety of AEDs during pregnancy and breastfeeding. By understanding the potential risks associated with different AEDs, we can work towards developing safer and more effective treatment strategies, protecting the neurological development of our children.

Dr. Camel's Conclusion

This systematic review sheds light on the complex landscape of AED safety for children exposed during pregnancy or breastfeeding. The findings highlight the importance of individualized treatment decisions, with valproate emerging as a drug associated with significantly increased odds of adverse neurodevelopmental outcomes. By navigating this research landscape with care and caution, we can work towards a brighter future for children living with epilepsy.

Date :
  1. Date Completed 2018-05-03
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

28729328

DOI: Digital Object Identifier

PMC5642793

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Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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