Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival.

Author: FinstererJosef, ScorzaFulvio A

Paper Details 
Original Abstract of the Article :
Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on mitochondria, which have a strong impact on the treatment of patients with a mitochondrial disorder (MID) with epilepsy (mitochondrial epilepsy). This review aims at summarizing and discussing recent findings concerning the effect ...See full text at original site
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引用元:
https://doi.org/10.1016/j.eplepsyres.2017.07.003

データ提供:米国国立医学図書館(NLM)

Antiepileptic Drugs and Mitochondria: A Complex Relationship

This study investigates the complex interplay between antiepileptic drugs (AEDs) and mitochondrial function. The authors provide a comprehensive review of recent findings concerning the effects of AEDs on mitochondria, highlighting both the beneficial and adverse effects. The study emphasizes the importance of understanding these interactions, particularly for patients with mitochondrial disorders (MID) and epilepsy. It also emphasizes the need for careful consideration of AED choice and dosage to optimize treatment outcomes and minimize potential complications.

Navigating the Challenges of Mitochondrial Epilepsy

The study sheds light on the crucial role that mitochondria play in the treatment of epilepsy. The findings underscore the need for personalized medicine approaches, taking into account individual patient characteristics and mitochondrial function. The study also calls for continued research to develop new AEDs with improved mitochondrial profiles, reducing the risk of adverse effects and enhancing treatment efficacy.

Mitochondrial Health: A Key to Effective Epilepsy Management

The research emphasizes the interconnectedness of mitochondrial health and epilepsy. It highlights the importance of maintaining optimal mitochondrial function for effective epilepsy management. This can involve lifestyle modifications, such as maintaining a healthy diet and engaging in regular exercise, as well as seeking medical advice on appropriate AEDs and their potential impact on mitochondrial function.

Dr. Camel's Conclusion

This research is like a camel traversing a desert landscape of complex neurological conditions. It highlights the intricate relationship between AEDs and mitochondrial function, emphasizing the importance of understanding these interactions to navigate the challenges of epilepsy and mitochondrial disorders. The journey to understand these conditions is as challenging as a desert trek, requiring perseverance, knowledge, and a commitment to improving patient outcomes.

Date :
  1. Date Completed 2018-05-07
  2. Date Revised 2018-05-16
Further Info :

Pubmed ID

28732239

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2017.07.003

Related Literature

SNS
PICO Info
in preparation
Languages

English

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