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Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein.

Author: CaoLihuan, JiangSongmin, LiuZulong, QuShijin, TanChangheng, TangLisha, YangXianmei, YuLong, YuWenbo, ZhuDayuan, ZhuHengrui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the anti-MDR effects of pyramidatine (Z88), a cinnamic acid-derived bisamide compound, on KB/VCR (vincristine-resistant human oral cancer cells) and MCF-7/ADR (adriamycin-resistant human breast adenocarcinoma) cells. Z88 was found to enhance the cytotoxicity of VCR toward KB/VCR cells and inhibit the function and expression of P-gp. These findings suggest that Z88 could be a potential reversal agent for MDR.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Multi-drug resistance (MDR) remains a major impediment in cancer therapy. A major goal for scientists is to discover more effective compounds that are able to circumvent MDR and simultaneously have minimal adverse side effects. OBJECTIVE: In the present study, we aim to determine the an...See full text at original site
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引用元：
https://doi.org/10.2174/1871520617666170803155025

データ提供：米国国立医学図書館（NLM）

Overcoming Multi-Drug Resistance in Cancer: The Role of Pyramidatine

Multi-drug resistance (MDR) is a significant obstacle in cancer treatment, often leading to treatment failure. This study investigates the potential of pyramidatine, a naturally occurring compound, in overcoming MDR in cancer cells. The researchers examined the effects of pyramidatine on vincristine-resistant human oral cancer cells (KB/VCR) and adriamycin-resistant human breast adenocarcinoma cells (MCF-7/ADR), evaluating its ability to enhance the effectiveness of chemotherapeutic agents.

Pyramidatine Shows Promise as an MDR Reversal Agent

The study found that pyramidatine significantly enhanced the cytotoxicity of vincristine towards KB/VCR cells. It also demonstrated that pyramidatine could inhibit the function and expression of P-glycoprotein (P-gp), a protein that pumps chemotherapeutic drugs out of cancer cells, thus contributing to MDR. These findings suggest that pyramidatine holds promise as a potential MDR reversal agent.

Fighting Cancer Resistance: A New Weapon in the Arsenal

This research provides a valuable contribution to the ongoing efforts to overcome MDR in cancer treatment. The findings suggest that pyramidatine could be a valuable tool in enhancing the effectiveness of chemotherapy drugs. Think of it like this: a camel traversing a desert might need to use a special tool to navigate a steep incline. Similarly, researchers are looking for tools to help them overcome the challenges of MDR in cancer therapy.

Dr. Camel's Conclusion

This study is a testament to the importance of ongoing research to find innovative solutions to overcome MDR in cancer. The promising results with pyramidatine offer hope for a more effective approach to treating drug-resistant cancers. The ongoing search for solutions to conquer MDR is a journey that requires perseverance, just like a camel navigating a vast and challenging desert.
Date :
  1. Date Completed 2019-07-29
  2. Date Revised 2019-09-11
Further Info :

Pubmed ID

28782465

DOI: Digital Object Identifier

10.2174/1871520617666170803155025

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