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Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.

Author: BenfieldP, HeelR C, LewisS P

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fluoxetine, a selective serotonin reuptake inhibitor, has demonstrated comparable efficacy to tricyclic antidepressants in treating unipolar depression. It is associated with fewer anticholinergic side effects and a favorable safety profile, making it a potential alternative for patients with depression.
Paper Details　
Original Abstract of the Article :
Fluoxetine is a new antidepressant which enhances serotoninergic neurotransmission through potent and selective inhibition of neuronal reuptake of serotonin. Metabolism by N-desmethylation occurs in man yielding desmethylfluoxetine, which also inhibits serotonin reuptake. Both the parent compound an...See full text at original site
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引用元：
https://doi.org/10.2165/00003495-198632060-00002

データ提供：米国国立医学図書館（NLM）

Fluoxetine: A New Oasis in the Desert of Depression

This study explores the pharmacodynamic and pharmacokinetic properties of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), and its efficacy in treating depressive illness. The research examines the drug's mechanism of action, its metabolism, and its therapeutic effects in comparison to traditional tricyclic antidepressants.

A New Path to Recovery: Fluoxetine for Depression

Fluoxetine has emerged as a promising treatment option for depression. This study highlights its comparable efficacy to traditional tricyclic antidepressants in relieving depressive symptoms, while offering a more favorable side effect profile. The research also explores the potential benefits of fluoxetine in treating other conditions, such as obsessive-compulsive disorder.

From Sandstorms to Serenity: Managing Depression

This study underscores the importance of exploring new and effective treatment options for depression. The research highlights the potential benefits of SSRIs, like fluoxetine, in managing depressive symptoms and improving quality of life. Fluoxetine's favorable side effect profile and its potential for long-term efficacy make it a valuable tool in the ongoing quest to better understand and treat depression.

Dr.Camel's Conclusion

This research explores the potential of fluoxetine, a selective serotonin reuptake inhibitor, as a promising treatment option for depression. The study's findings suggest that fluoxetine offers a favorable side effect profile and comparable efficacy to traditional tricyclic antidepressants. This research highlights the importance of exploring new and effective treatment options for depression, potentially leading to improved outcomes and enhanced quality of life for patients.

Date :
  1. Date Completed 1987-02-10
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

2878798

DOI: Digital Object Identifier

10.2165/00003495-198632060-00002

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