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ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348.

Author: CheanJennifer, ChenCharng-Jui, ShivelyJohn E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study looked at the relationship between a gene called CEACAM1 and breast cancer. The study found that restoring CEACAM1 expression can reverse malignant changes in breast cells.
Paper Details　
Original Abstract of the Article :
The loss of expression of a single gene can revert normal tissue to a malignant phenotype. For example, while normal breast has high lumenal expression of CEACAM1, the majority of breast cancers exhibit the early loss of this gene with the concurrent loss of their lumenal phenotype. MCF7 cells that ...See full text at original site
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引用元：
https://doi.org/10.1016/j.yexcr.2017.08.008

データ提供：米国国立医学図書館（NLM）

ETS Transcription Factor ELF5 and Lumen Formation in Mammary Morphogenesis

In the field of [cancer biology], researchers are constantly seeking to understand the complex mechanisms that underlie the development and progression of [cancer]. This study focuses on the role of [ETS transcription factor ELF5] in [mammary morphogenesis], the process by which the [breast tissue] develops and forms its characteristic structures. The researchers investigated the effects of [ELF5] expression on [lumen formation], a crucial aspect of [normal breast tissue] development.

ELF5: A Key Regulator of Mammary Morphogenesis

The study found that [ELF5] plays a critical role in [lumen formation] in a [3D model of mammary morphogenesis]. The researchers discovered that [ELF5] expression is [inhibited by Jak2 inhibitor TG101348], a finding that suggests a potential link between [Jak2 signaling] and [mammary morphogenesis]. This study provides valuable insights into the intricate mechanisms that regulate [breast tissue] development and highlights the importance of [ELF5] in this process.

Lumen Formation: A Crucial Aspect of Breast Tissue Development

This research underscores the significance of [lumen formation] in the development of [normal breast tissue]. The study suggests that [ELF5] is a key regulator of this process and that its dysregulation could potentially contribute to the development of [breast cancer]. Further research is needed to fully understand the complex interplay between [ELF5], [Jak2 signaling], and [mammary morphogenesis] to develop targeted therapies for [breast cancer].

Dr.Camel's Conclusion

This study is a fascinating journey into the desert of [cancer biology], revealing the intricate mechanisms that govern the development of [breast tissue]. The discovery of [ELF5]'s role in [lumen formation] provides valuable insights into the potential pathways for [breast cancer] development and offers promising avenues for future research and therapeutic interventions.

Date :
  1. Date Completed 2017-10-16
  2. Date Revised 2022-06-13
Further Info :

Pubmed ID

28800960

DOI: Digital Object Identifier

10.1016/j.yexcr.2017.08.008

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