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Anticholinergic equivalents and parkinsonism: a model for predicting side-effects of antipsychotic drugs.

Author: Caradoc-DaviesG, ClarksonH O, MenkesD B, MullenP E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The balance between antipsychotic and antimuscarinic activity was found to be crucial for managing extrapyramidal side effects, suggesting a potential for optimizing antiparkinson drug requirements.
Paper Details　
Original Abstract of the Article :
The tendency of antipsychotics to produce extrapyramidal side-effects varies inversely with their antimuscarinic activity. This paper reviews the antipsychotic and antimuscarinic potency of these drugs and compares the total antimuscarinic activity in standard daily doses of antipsychotics, antipark...See full text at original site
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引用元：
https://doi.org/10.1097/00004850-198701000-00005

データ提供：米国国立医学図書館（NLM）

Antipsychotics: A Balancing Act of Side Effects

This study takes us on a journey through the desert of antipsychotic medications, exploring their complex effects on the brain and body. The researchers investigate the relationship between anticholinergic activity, which blocks certain brain chemicals, and the risk of extrapyramidal side effects, a group of movement disorders that can occur as a side effect of antipsychotic medications. It's like navigating a desert landscape, where the terrain can be challenging and unexpected hazards can arise.

A Balancing Act of Effects

This study highlights the importance of finding the right balance between the therapeutic effects and potential side effects of antipsychotic medications, like finding the optimal path through a desert, considering the potential risks and rewards. The researchers propose a model for predicting the risk of extrapyramidal side effects based on the relative doses of antipsychotic and anticholinergic medications, providing a guide for clinicians to make informed decisions about treatment regimens.

Navigating the Desert of Antipsychotics

This study offers valuable insights into the management of antipsychotic medication, emphasizing the importance of careful monitoring and individualized treatment approaches to minimize the risk of side effects. It's like navigating a desert, where understanding the terrain and using the right tools can make all the difference in reaching the destination safely.

Dr. Camel's Conclusion

This research explores the relationship between anticholinergic activity and extrapyramidal side effects associated with antipsychotic medications, emphasizing the importance of individualized treatment approaches and careful monitoring to minimize potential risks.

Date :
  1. Date Completed 1987-12-04
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

2889760

DOI: Digital Object Identifier

10.1097/00004850-198701000-00005

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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