Benefit-Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis.

Author: BakshiRajesh, ComiGiancarlo, HartungHans-Peter, WiendlHeinz, WilliamsIan M

Paper Details 
Original Abstract of the Article :
Since the approval of fingolimod, several selective sphingosine-1-phosphate receptor modulators have entered clinical development for multiple sclerosis. However, side effects can occur with sphingosine-1-phosphate receptor modulators. By considering short-term data across the drug class and longer ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661009/

データ提供:米国国立医学図書館(NLM)

Sphingosine-1-Phosphate Receptor Modulators: A Promising Therapy for Multiple Sclerosis

The field of neurology is constantly searching for new and effective therapies for chronic neurological disorders. This research examines the benefit-risk profile of sphingosine-1-phosphate receptor modulators, a class of drugs that show promise for treating multiple sclerosis (MS). The study reviews available data to assess the efficacy, safety, and long-term implications of these drugs for managing MS.

Sphingosine-1-Phosphate Receptor Modulators: A Balancing Act

The study highlights the effectiveness of sphingosine-1-phosphate receptor modulators in reducing MS relapses and slowing disease progression. However, it also acknowledges potential side effects, including cardiac events, macular edema, infection, and malignancy. The study emphasizes the importance of carefully weighing these risks and benefits when considering treatment with these drugs.

Long-Term Management of MS: A Promising Future

This research suggests that sphingosine-1-phosphate receptor modulators offer a promising long-term treatment option for MS. The study's review of short-term and long-term data indicates that these drugs can be effective and safe for long-term use. Furthermore, the study highlights the potential for improved patient satisfaction and treatment persistence with these drugs compared to injectable therapies.

Dr. Camel's Conclusion

Imagine a desert oasis, where the cool waters of a spring offer respite from the harsh heat. This research explores the potential of sphingosine-1-phosphate receptor modulators as a therapeutic oasis for individuals with MS. While these drugs offer promise for managing MS, it's important to approach treatment with a thoughtful understanding of their potential risks and benefits. Just as a traveler in the desert needs to carefully navigate the landscape, clinicians need to assess the individual needs of each patient to ensure safe and effective treatment with these drugs. This research provides valuable information to guide informed decision-making and optimize patient care.

Date :
  1. Date Completed 2018-11-19
  2. Date Revised 2019-07-25
Further Info :

Pubmed ID

28905255

DOI: Digital Object Identifier

PMC5661009

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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