Phase I/II Trial of Anticarcinoembryonic Antigen Radioimmunotherapy, Gemcitabine, and Hepatic Arterial Infusion of Fluorodeoxyuridine Postresection of Liver Metastasis for Colorectal Carcinoma.

Author: CahanBenjamin, ColcherDavid, FrankelPaul, LeongLucille, RaubitschekAndrew, ShibataStephen, ShivelyJohn, WagmanLawrence, WilliamsLawrence E, WilzcynskiSharon, WongJeffrey Y C, WuAnna, YamauchiDavid, YazakiPaul

Paper Details 
Original Abstract of the Article :
Label="OBJECTIVES" NlmCategory="OBJECTIVE">Report the feasibility, toxicities, and long-term results of a Phase I/II trial of <sup>90</sup>Y-labeled anticarcinoembryonic antigen (anti-CEA) (cT84.66) radioimmunotherapy (RIT), gemcitabine, and hepatic arterial infusion (HAI) of fluorodeoxyuridine (FUd...See full text at original site
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引用元:
https://doi.org/10.1089/cbr.2017.2223

データ提供:米国国立医学図書館(NLM)

Radioimmunotherapy, Gemcitabine, and Hepatic Arterial Infusion for Colorectal Liver Metastasis

This research investigates the feasibility, toxicity, and long-term outcomes of a combined treatment approach for colorectal liver metastasis. The study utilizes a Phase I/II trial design to assess the safety and effectiveness of 90Y-labeled anticarcinoembryonic antigen (anti-CEA) radioimmunotherapy (RIT), gemcitabine, and hepatic arterial infusion (HAI) of fluorodeoxyuridine (FUdR) after liver resection.

A Multimodal Approach to Treating Colorectal Liver Metastasis

The study explores a novel combination therapy for colorectal liver metastasis, aiming to enhance treatment outcomes and improve patient survival. The use of radioimmunotherapy, chemotherapy, and regional drug delivery strategies is designed to target cancer cells effectively.

Evaluating the Safety and Efficacy of Multimodal Therapy

The study provides valuable insights into the safety and efficacy of this multipronged treatment approach. Further research is needed to confirm the long-term benefits and optimize treatment strategies for colorectal liver metastasis.

Dr. Camel's Conclusion

This study underscores the importance of exploring innovative treatment options for colorectal cancer. Dr. Camel notes that just as the camel adapts its feeding habits based on the availability of resources, researchers are constantly searching for new ways to combat this challenging disease. The study highlights the potential of multimodal therapies in improving treatment outcomes for colorectal liver metastasis.

Date :
  1. Date Completed 2018-05-16
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

28910150

DOI: Digital Object Identifier

10.1089/cbr.2017.2223

Related Literature

SNS
PICO Info
in preparation
Languages

English

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