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Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors.

Author: Contreras-GalindoRafael, DubeDerek, FujinagaKoh, KaplanMark H, MarkovitzDavid M

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the efficacy of commercially available reverse transcriptase inhibitors (RTIs) in inhibiting the activity of human endogenous retroviruses (HERVs), specifically the HERV type K (HERV-K) HML-2 (HK2) family. The results demonstrated that several nucleoside analogue RTIs effectively blocked HK2 replication, suggesting their potential for suppressing HK2 activity in diseases associated with these viruses.
Paper Details　
Original Abstract of the Article :
Human endogenous retroviruses (HERVs) make up 8% of the human genome. The HERV type K (HERV-K) HML-2 (HK2) family contains proviruses that are the most recent entrants into the human germ line and are transcriptionally active. In HIV-1 infection and cancer, HK2 genes produce retroviral particles tha...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686744/

データ提供：米国国立医学図書館（NLM）

Human Endogenous Retrovirus Type K: A New Oasis in the Desert of Viral Infections

The human genome is a vast and intricate desert, where remnants of ancient viral infections, known as endogenous retroviruses (HERVs), lie dormant. This study investigates the susceptibility of HERV type K (HERV-K) to reverse transcriptase inhibitors (RTIs), drugs commonly used to treat HIV-1 infection.

A Promising Oasis in the Desert of Viral Infections: HERV-K Inhibition

The study's findings, like a hidden spring in the desert, suggest that several nucleoside analogue RTIs (NRTIs) effectively inhibit HERV-K replication. This discovery raises intriguing possibilities for potential treatments for diseases associated with HERV-K reactivation.

Navigating the Desert of Viral Research: A New Path Forward

The study emphasizes the importance of understanding the replication mechanisms of HERVs and exploring the potential of repurposing existing antiviral drugs for new therapeutic applications.

Dr.Camel's Conclusion

The human genome is a vast and mysterious desert, where dormant viruses may lurk. This study offers a glimmer of hope, suggesting that existing antiviral drugs could potentially be used to combat HERV-K reactivation, opening new frontiers in viral research and treatment.

Date :
  1. Date Completed 2017-12-06
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28931682

DOI: Digital Object Identifier

PMC5686744

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Languages

English

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