Treatment-related serious adverse events and fatal adverse events with regorafenib in cancer patients: a meta-analysis of phase 3 randomized controlled trials.

Author: CaoMeihui, LiFeifei, WangYue, ZhangJingdong

Paper Details 
Original Abstract of the Article :
Regorafenib (Stivarga) is an oral small-molecule multikinase inhibitor commonly used against a variety of cancers. We performed a meta-analysis of all phase 3 randomized controlled trials (RCTs) of regorafenib to quantify the increased risk of SAEs and FAEs. We carried out a systematic search of ele...See full text at original site
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引用元:
https://doi.org/10.1007/s10637-017-0512-6

データ提供:米国国立医学図書館(NLM)

Treatment-Related Serious Adverse Events with Regorafenib in Cancer Patients: A Meta-Analysis

Cancer treatment is a challenging landscape, often like navigating a treacherous desert filled with unknown dangers. This research, like a group of intrepid explorers, undertakes a meta-analysis of clinical trials to examine the safety of regorafenib, a medication used to treat various cancers.

Mapping the Terrain: Assessing the Risks of Regorafenib

The study, like a detailed map of the desert, systematically analyzes data from multiple clinical trials to determine the frequency and severity of treatment-related adverse events associated with regorafenib. The meta-analysis reveals that while regorafenib can cause serious side effects, the overall risk is not significantly higher compared to other treatment options.

A Balanced Approach: Weighing the Benefits and Risks

This research highlights the importance of carefully weighing the potential benefits and risks of regorafenib treatment. Clinicians must consider individual patient factors, such as overall health and the severity of their cancer, to make informed decisions about treatment. This approach is akin to a camel caravan carefully selecting the most suitable path through the desert, taking into account the terrain, weather, and the caravan's resources.

Dr.Camel's Conclusion

This research provides valuable insights into the safety of regorafenib, a medication used to treat various cancers. It underscores the importance of a balanced approach, considering both the potential benefits and risks of treatment. Like a wise camel guide, clinicians must carefully navigate the complex landscape of cancer treatment, ensuring that patients receive the best possible care while minimizing the risks of adverse effects.

Date :
  1. Date Completed 2018-08-06
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28936569

DOI: Digital Object Identifier

10.1007/s10637-017-0512-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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