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Treatment-related serious adverse events and fatal adverse events with regorafenib in cancer patients: a meta-analysis of phase 3 randomized controlled trials.
Author: CaoMeihui, LiFeifei, WangYue, ZhangJingdong
Original Abstract of the Article :
Regorafenib (Stivarga) is an oral small-molecule multikinase inhibitor commonly used against a variety of cancers. We performed a meta-analysis of all phase 3 randomized controlled trials (RCTs) of regorafenib to quantify the increased risk of SAEs and FAEs. We carried out a systematic search of ele...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s10637-017-0512-6
データ提供:米国国立医学図書館(NLM)
Treatment-Related Serious Adverse Events with Regorafenib in Cancer Patients: A Meta-Analysis
Cancer treatment is a challenging landscape, often like navigating a treacherous desert filled with unknown dangers. This research, like a group of intrepid explorers, undertakes a meta-analysis of clinical trials to examine the safety of regorafenib, a medication used to treat various cancers.
Mapping the Terrain: Assessing the Risks of Regorafenib
The study, like a detailed map of the desert, systematically analyzes data from multiple clinical trials to determine the frequency and severity of treatment-related adverse events associated with regorafenib. The meta-analysis reveals that while regorafenib can cause serious side effects, the overall risk is not significantly higher compared to other treatment options.
A Balanced Approach: Weighing the Benefits and Risks
This research highlights the importance of carefully weighing the potential benefits and risks of regorafenib treatment. Clinicians must consider individual patient factors, such as overall health and the severity of their cancer, to make informed decisions about treatment. This approach is akin to a camel caravan carefully selecting the most suitable path through the desert, taking into account the terrain, weather, and the caravan's resources.
Dr.Camel's Conclusion
This research provides valuable insights into the safety of regorafenib, a medication used to treat various cancers. It underscores the importance of a balanced approach, considering both the potential benefits and risks of treatment. Like a wise camel guide, clinicians must carefully navigate the complex landscape of cancer treatment, ensuring that patients receive the best possible care while minimizing the risks of adverse effects.
Date :
- Date Completed 2018-08-06
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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