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SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells.

Author: DinarvandRassoul, IraniShiva, MirfakhraieReza, NaghehZahra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

SN38-PEG-PLGA-Ver NPs is a new drug delivery system that can deliver the cancer drug irinotecan more effectively to cancer cells. The drug delivery system was shown to be effective in killing cancer cells and reducing the resistance of cancer cells to irinotecan.
Paper Details　
Original Abstract of the Article :
Nowadays, nanoparticle-based drug delivery systems are recognized to reduce the therapeutic side effects. One of the common problems in cancer treatment is cancer drug resistance, resulting from the over-expression of one energy-dependent transporter that enhances drug efflux. Irinotecan is used for...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700907/

データ提供：米国国立医学図書館（NLM）

Overcoming Drug Resistance in Colorectal Cancer: Nanoparticles to the Rescue

Cancer treatment often faces the formidable challenge of drug resistance, where cancer cells develop mechanisms to evade the effects of chemotherapy. This research explores a novel nanoparticle-based drug delivery system designed to overcome drug resistance in colorectal cancer, focusing on the delivery of SN38, a potent anti-cancer agent derived from irinotecan. The study investigates the efficacy of SN38-loaded pegylated PLGA-verapamil nanoparticles (NPs) in inhibiting the growth of colorectal cancer cells and downregulating the expression of a key drug transporter protein, ABCG2.

A Targeted Approach to Drug Delivery

The researchers found that SN38-PEG-PLGA-Ver NPs effectively inhibited the proliferation of colorectal cancer cells and downregulated the expression of ABCG2, suggesting that this nanoparticle system can overcome drug resistance by directly targeting the transporter protein. This promising approach offers a potential solution for the treatment of drug-resistant colorectal cancer.

A New Era of Personalized Cancer Treatment

This research highlights the exciting potential of nanoparticle-based drug delivery systems in personalized cancer therapy. By targeting specific pathways within cancer cells, these systems can deliver drugs more effectively and minimize side effects. It points towards a future where treatment plans are tailored to the unique characteristics of each patient's cancer, offering hope for improved outcomes.

Dr.Camel's Conclusion

This study demonstrates the immense potential of nanotechnology in the fight against cancer. By developing targeted drug delivery systems, researchers are opening new avenues for effective treatment and potentially paving the way for personalized cancer therapies. It's a reminder that scientific innovation is a continuous journey, driven by the desire to overcome seemingly insurmountable challenges and improve the lives of those affected by cancer.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

28948511

DOI: Digital Object Identifier

PMC5700907

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Languages

English

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