Anti-HCV treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir is associated with increased bile acid levels and pruritus.

Author: FaulerGünter, KesslerHarald H, LeberBettina, ManggeHarald, PoschAndreas, RainerFlorian, SpindelboeckWalter, StadlbauerVanessa, StauberRudolf E, StreitAndrea

Paper Details 
Original Abstract of the Article :
Direct acting antiviral (DAA)-based treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir (OBV/PTV/r ± DSV) is highly effective in HCV genotype 1 or 4 infection and well-tolerated with only few side effects. However, pruritus has been observed in several trials in up to 20% of patients and se...See full text at original site
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引用元:
https://doi.org/10.1007/s00508-017-1268-x

データ提供:米国国立医学図書館(NLM)

Navigating the Side Effects of HCV Treatment: A Case of Pruritus

The [treatment of hepatitis C virus (HCV) infection] has seen significant advancements with the development of [direct acting antiviral (DAA) therapies]. This study focuses on a specific DAA combination, [ombitasvir/paritaprevir/ritonavir ± dasabuvir (OBV/PTV/r ± DSV)], which has demonstrated remarkable efficacy in treating [HCV genotype 1 or 4 infection]. While generally well-tolerated, the authors highlight the [occurrence of pruritus] in a significant proportion of patients treated with this combination. The study underscores the importance of [monitoring for side effects] and providing appropriate [management strategies] to improve patient comfort and adherence to treatment.

The Price of Progress: Pruritus and HCV Treatment

The study's findings underscore the importance of recognizing and managing potential side effects associated with [DAA therapy], even when these treatments are highly effective. The occurrence of [pruritus] in patients treated with [OBV/PTV/r ± DSV] highlights the need for [close monitoring] and [individualized treatment strategies] to optimize patient outcomes. It's a reminder that even in the desert of disease, the path to recovery may not always be smooth.

Managing HCV: A Journey with Challenges and Triumphs

As a traveler through the complex landscape of viral infections, I find this study particularly relevant. The advent of DAA therapies has been a beacon of hope in the fight against HCV. However, this study reminds us that even in the most effective treatments, side effects can occur. It's essential to be aware of these potential challenges and work closely with your healthcare provider to ensure a smooth and successful journey to recovery.

Dr. Camel's Conclusion

The treatment of HCV infection is a journey with both challenges and triumphs. While DAAs have revolutionized treatment, this study reminds us of the importance of managing potential side effects. It's a journey where both medical advancements and attentive care are needed to navigate the path to recovery.

Date :
  1. Date Completed 2018-10-26
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

28980064

DOI: Digital Object Identifier

10.1007/s00508-017-1268-x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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