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HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.

Author: BecquemontLaurent, NegriniSimone

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Adverse drug reactions are a major cause of morbidity and mortality. Some reactions are unpredictable and seem to occur in genetically predisposed individuals. A growing number of studies show that specific HLA alleles increase the risk of hypersensitivity drug reactions.
Paper Details　
Original Abstract of the Article :
Adverse drug reactions are an important cause of morbidity and mortality and constitute the leading reason of drug withdrawal from the market. Besides classical reactions that are related to pharmacologic activity of the drug, some reactions are unpredictable, not dose dependent, and seem to occur i...See full text at original site
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引用元：
https://doi.org/10.2217/pgs-2017-0090

データ提供：米国国立医学図書館（NLM）

Understanding Drug Hypersensitivity: The Role of HLA

This study delves into the complex world of adverse drug reactions, exploring the genetic factors that contribute to hypersensitivity reactions. The study focuses on the role of human leukocyte antigen (HLA) alleles in predicting the risk of developing hypersensitivity reactions to certain medications. HLA alleles are important components of the immune system, playing a crucial role in recognizing and responding to foreign substances, including medications.

Genetic Predisposition to Drug Hypersensitivity

The study highlights the growing body of evidence suggesting that specific HLA alleles increase the risk of developing hypersensitivity reactions to certain drugs. This genetic predisposition can make certain individuals more vulnerable to experiencing severe and even life-threatening reactions to medications.

Personalized Medicine and Drug Safety

This research underscores the importance of personalized medicine in drug safety. By understanding the genetic factors that influence drug responses, healthcare professionals can better predict and manage potential hypersensitivity reactions, ensuring patient safety and optimizing treatment outcomes.

Dr.Camel's Conclusion

Imagine the human body as a vast desert landscape, with a complex network of immune cells navigating the terrain. Just as certain desert plants are uniquely adapted to their environment, specific HLA alleles can make individuals more susceptible to certain drugs. This research emphasizes the importance of understanding these genetic variations to ensure safe and effective medication use, protecting individuals from the hazards of unpredictable immune responses.
Date :
  1. Date Completed 2018-07-13
  2. Date Revised 2018-07-13
Further Info :

Pubmed ID

29017379

DOI: Digital Object Identifier

10.2217/pgs-2017-0090

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English

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