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Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses.

Author: BrouxB, CroubelsS, De ClercqD, DecloedtA, DevreeseM, GehringR, VeraL, van LoonG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the pharmacokinetics of sotalol, a β-blocker with class III anti-arrhythmic properties, in horses. The study found that sotalol significantly increased the QT interval and effective refractory periods (ERPs) at doses of 2, 3, and 4 mg/kg bodyweight twice daily. Higher doses did not result in a progressive increase in QT interval or ERPs. The study concluded that sotalol may be a useful drug for long-term anti-arrhythmic therapy in horses.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Arrhythmias in horses may require long-term anti-arrhythmic therapy. Unfortunately, oral anti-arrhythmic drugs for use in horses are currently scarce. In human patients and small animals, sotalol, a β-blocker with class III anti-arrhythmic properties, is often used for long-term treatmen...See full text at original site
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引用元：
https://doi.org/10.1111/evj.12765

データ提供：米国国立医学図書館（NLM）

Pharmacokinetics and Electrophysiological Effects of Sotalol Hydrochloride in Horses

The world of veterinary medicine is constantly expanding, seeking solutions for our animal companions that are as diverse as the desert landscape. This study explores the pharmacokinetics and electrophysiological effects of sotalol, a drug used to treat arrhythmias, in horses. Researchers investigated the drug's effects on heart rhythm and function in these animals, aiming to find safe and effective treatment options for equine arrhythmias.

Sotalol's Effects on Horse Heart Rhythm

This study provides valuable information about the pharmacokinetics and electrophysiological effects of sotalol in horses. The authors found that sotalol effectively prolonged the QT interval and effective refractory periods in the heart, suggesting its potential for treating arrhythmias in horses. Just as a camel's heart adapts to the extremes of desert temperatures, this research aims to help horses maintain a steady and healthy heart rhythm.

Expanding Treatment Options for Equine Arrhythmias

This study expands our understanding of sotalol's effects in horses, offering a potential new treatment option for equine arrhythmias. It's a testament to the ongoing efforts to develop safe and effective medications for animals, just as we strive to protect the delicate desert ecosystem.

Dr.Camel's Conclusion

This study provides valuable data on the pharmacokinetics and electrophysiological effects of sotalol in horses, suggesting its potential use for treating equine arrhythmias. This research is a reminder of the importance of ongoing research and innovation in veterinary medicine, ensuring the health and well-being of our animal companions.
Date :
  1. Date Completed 2018-04-27
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

29023952

DOI: Digital Object Identifier

10.1111/evj.12765

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・Side Effects of sotalol
SNS
PICO Info
in preparation
Languages

English

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