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A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in patients with advanced melanoma: a single-centre experience.

Author: AlaibacMauro, Chiarion SileniVanna, FrigoAnna Chiara, RussoIrene, ZorzettoLudovica

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Overview

BRAF inhibitors are effective in treating advanced melanoma, but they can cause significant skin side effects. This study found that the combination therapy with BRAF and MEK inhibitors is associated with a different pattern of skin side effects compared to BRAF inhibitor monotherapy.
Paper Details　
Original Abstract of the Article :
Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug...See full text at original site
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引用元：
https://doi.org/10.1684/ejd.2017.3069

データ提供：米国国立医学図書館（NLM）

Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma

Melanoma, a serious form of skin cancer, can be like a stubborn desert weed, persistent and difficult to eradicate. This study compares the cutaneous side effects of two different BRAF inhibitor therapies used in the treatment of advanced melanoma: BRAF monotherapy and BRAF/MEK inhibitor combination therapy. The authors meticulously analyzed the medical records of patients who received these therapies, revealing important differences in their respective side effect profiles. This study, like a careful botanist examining the delicate ecosystems of a desert, provides valuable insights into the nuances of these therapies.

Navigating the Desert of Melanoma Treatment

The study found that both monotherapy and combination therapy can lead to various cutaneous side effects, but the types of side effects differed significantly. This research, like a compass guiding us through the desert of melanoma treatment, helps us understand the unique characteristics of these therapies.

The Importance of Personalized Treatment

The findings of this study underscore the importance of individualizing treatment approaches for melanoma patients, taking into account the potential benefits and risks of each therapy. This research, like a desert caravan with diverse members, emphasizes the need for a personalized approach to care.

Dr.Camel's Conclusion

This study highlights the importance of careful monitoring and managing cutaneous side effects in melanoma patients, reminding us that even in the harsh landscape of cancer treatment, we must strive to ensure the well-being of our patients.

Date :
  1. Date Completed 2018-05-29
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

29084636

DOI: Digital Object Identifier

10.1684/ejd.2017.3069

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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