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Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders.

Author: , AbellThomas L, ClarkeJohn O, DhallaSameer, FarrugiaGianrico, GroverMadhusudan, HamiltonFrank A, HaslerWilliam L, KochKenneth L, LeeLinda A, McCallumRichard W, MirielLaura A, NguyenLinda Anh B, ParkmanHenry P, PasrichaPankaj J, SarosiekIrene, SnapeWilliam J, SteinEllen M, TonasciaJames, Van NattaMark L, YatesKatherine P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A randomized trial evaluated the effectiveness of aprepitant, a neurokinin-1 receptor antagonist, in reducing nausea and vomiting in patients with gastroparesis or gastroparesis-like syndrome.
Paper Details　
Original Abstract of the Article :
There are few effective treatments for nausea and other symptoms in patients with gastroparesis and related syndromes. We performed a randomized trial of the ability of the neurokinin-1 receptor antagonist aprepitant to reduce symptoms in patients with chronic nausea and vomiting caused by gastropar...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29111115

データ提供：米国国立医学図書館（NLM）

Aprepitant: A New Oasis in the Desert of Gastroparesis

Gastroparesis, a condition characterized by delayed gastric emptying, is a debilitating ailment, like a persistent mirage in the desert. Patients often struggle with nausea and vomiting, significantly impacting their quality of life. This study examines the effectiveness of aprepitant, a neurokinin-1 receptor antagonist, in alleviating these symptoms.

The research involved a randomized trial of aprepitant in patients with chronic nausea and vomiting caused by gastroparesis. While aprepitant did not completely alleviate nausea, it did provide some relief and reduced other symptoms, offering a glimmer of hope in the desert of gastroparesis.

A Promising Step Forward in Gastroparesis Management

This study provides valuable insights into the potential of aprepitant in managing gastroparesis. While it is not a cure, it represents a promising step forward in alleviating symptoms and improving the lives of individuals affected by this debilitating condition. Further research is crucial to explore its full potential and optimize its use in managing gastroparesis.

Dr. Camel's Conclusion

Gastroparesis, like a deceptive mirage, often leaves patients feeling lost in the desert of discomfort. This study explores aprepitant, a potential oasis in this barren landscape, offering a glimmer of relief from nausea and vomiting. While aprepitant's effects are not a complete cure, they provide a beacon of hope for individuals grappling with this condition. Further research is essential to expand our knowledge of this promising therapeutic agent and its potential to bring solace to those affected by gastroparesis.

Date :
  1. Date Completed 2018-04-16
  2. Date Revised 2019-01-07
Further Info :

Pubmed ID

29111115

DOI: Digital Object Identifier

NIHMS917374

Related Literature

Article Analysis
・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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