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Induction of oxidative stress by anticancer drugs in the presence and absence of cells.
Author: EmaMika, HisatomiHisashi, MoriYumi, SueyoshiYuto, TakaishiKazuto, YokoyamaChikako
Original Abstract of the Article :
Reactive oxygen species (ROS) are generated in the cell through multiple mechanisms. Intracellular ROS are rapidly detoxified by various enzymatic and non-enzymatic mechanisms; however, disruption of the oxidant-antioxidant balance causes oxidative stress and elicits cell damage. The oxidative stres...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661396/
データ提供：米国国立医学図書館（NLM）
Oxidative Stress and Anticancer Drugs: A Tale of Two Worlds
The world of cancer treatment is like a vast desert, where researchers are constantly seeking new ways to combat this disease. This study dives into the complex relationship between anticancer drugs and oxidative stress. Oxidative stress, like a fierce sandstorm, can damage cells. The study investigates whether these drugs induce oxidative stress in cancer cells. They found that certain anticancer drugs like nimustine, actinomycin D, and doxorubicin can indeed cause oxidative stress, both in the presence and absence of cancer cells. The study's findings provide valuable insights into the mechanisms by which these drugs work and potential side effects.
Oxidative Stress: A Double-Edged Sword
This study sheds light on the complex nature of oxidative stress in cancer treatment. While it can help fight cancer cells, it can also harm healthy cells. The researchers found that specific anticancer drugs can directly induce oxidative stress, even in the absence of cancer cells. This discovery is crucial for understanding the balance between fighting the disease and minimizing potential side effects.
Navigating the Side Effects of Cancer Treatment
The side effects of cancer treatment can be challenging for patients. This research helps doctors better understand the mechanisms behind these side effects, specifically oxidative stress. This knowledge can be used to develop strategies for minimizing these effects and improving the overall quality of life for patients undergoing chemotherapy.
Dr. Camel's Conclusion
This research highlights the complex interplay between anticancer drugs and oxidative stress. By understanding how these drugs work at a cellular level, researchers can develop more targeted therapies that maximize cancer-killing effects while minimizing side effects. It's like finding a hidden oasis in the desert, providing a safe haven for patients during their journey through cancer treatment.
Date :
- Date Completed n.d.
- Date Revised 2020-09-30
Further Info :
Related Literature
English
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