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Psychotropic agent thioridazine elicits potent in vitro and in vivo anti-melanoma effects.
Author: ChenZhixing, JiangXiaoshuang, JiangYong, LiXue, ShenGuobo, WangGuoping, WuLiangjun, YinTao
Original Abstract of the Article :
Psychotropic agents have been shown anti-tumor potential in recent years. In the present study, our in vitro pharmacological data indicated that thioridazine inhibited melanoma cells proliferation. The growth-arresting effect of thioridazine was accompanied by autophagy induction, as shown by immuno...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.biopha.2017.11.012
データ提供:米国国立医学図書館(NLM)
Thioridazine: A Potential New Weapon Against Melanoma
In the ongoing battle against [melanoma], researchers are constantly searching for new and effective therapies. This study examines the surprising [anti-melanoma effects] of [thioridazine], a medication primarily known for its use in [treating psychiatric conditions]. The authors discovered that thioridazine effectively inhibited [melanoma cell proliferation] in vitro, a finding that was further validated in vivo through [tumor growth retardation] in mice. The research suggests that thioridazine's anti-melanoma activity may be mediated through [induction of autophagy and apoptotic pathways], processes that can lead to the death of cancer cells. This research is like a desert oasis, offering a potential new treatment option for a challenging form of cancer.Expanding the Arsenal Against Melanoma
The study's findings provide a glimmer of hope for [melanoma patients] who may have exhausted traditional treatment options. Thioridazine, with its [dual anti-cancer mechanisms], offers a novel and potentially effective strategy for combating melanoma. This research highlights the importance of [exploring new therapeutic avenues], just as a desert explorer ventures into uncharted territories in search of valuable resources.Navigating the Complexities of Cancer Treatment
The research emphasizes the importance of [understanding the specific mechanisms] by which medications work. Thioridazine's [dual action] on autophagy and apoptosis suggests that it may be more effective than drugs that target only one pathway. This research is a reminder that the vast desert of cancer treatment is filled with complex interactions, and we must carefully consider all potential pathways to finding effective therapies.Dr.Camel's Conclusion
This study offers a fascinating and unexpected discovery in the fight against melanoma. Thioridazine, a medication previously known for its use in mental health, shows promise as a potential new treatment option for this challenging disease. As a wise camel, I encourage everyone to stay informed about the latest developments in cancer research and to seek the guidance of qualified professionals for personalized treatment strategies.Date :
- Date Completed 2018-08-01
- Date Revised 2020-12-30
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