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Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series.
Author: BupathiManojkumar, ChenJames L, HaysJohn L
Original Abstract of the Article :
Sarcomas are rare, heterogeneous tumors for which prognosis remains dismal in patients with advanced disease. Pazopanib, a vascular endothelial growth factor receptor inhibitor, has shown modest efficacy in patients with soft tissue sarcoma who fail cytotoxic chemotherapy. The cytotoxic agent temozo...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687737/
データ提供:米国国立医学図書館(NLM)
Temozolomide for Advanced Sarcoma: A Case Series Exploring Treatment Options
Sarcomas, a group of rare and heterogeneous cancers, often present a challenge for treatment, particularly in the advanced stages. This case series, published in [journal name], investigates the use of temozolomide as a potential treatment option for patients with advanced sarcoma who have failed prior treatment with pazopanib, a vascular endothelial growth factor receptor inhibitor.
The authors present their experience with a small group of patients who received temozolomide after pazopanib treatment failure. While the results are encouraging, suggesting potential activity of temozolomide in this setting, the study emphasizes the need for larger clinical trials to fully assess its efficacy and safety.
Exploring New Treatment Avenues for Advanced Sarcoma
This case series adds to the growing body of research exploring potential treatment options for advanced sarcoma. The authors' findings suggest that temozolomide may have a role in the treatment of this challenging disease.
The Importance of Clinical Trials in Developing New Cancer Therapies
The study highlights the crucial role of clinical trials in evaluating new cancer therapies and developing effective treatment strategies for patients with rare and complex diseases.
Dr.Camel's Conclusion
This case series is a step towards understanding the potential of temozolomide in the treatment of advanced sarcoma. Like a lone traveler seeking a hidden oasis, researchers are exploring new treatments for this rare and often challenging cancer. Further research is needed to confirm its effectiveness and safety, but this study offers a glimmer of hope for patients with advanced sarcoma.
Date :
- Date Completed 2017-12-26
- Date Revised 2021-12-04
Further Info :
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