Paper Details 
Original Abstract of the Article :
Sarcomas are rare, heterogeneous tumors for which prognosis remains dismal in patients with advanced disease. Pazopanib, a vascular endothelial growth factor receptor inhibitor, has shown modest efficacy in patients with soft tissue sarcoma who fail cytotoxic chemotherapy. The cytotoxic agent temozo...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687737/

データ提供:米国国立医学図書館(NLM)

Temozolomide for Advanced Sarcoma: A Case Series Exploring Treatment Options

Sarcomas, a group of rare and heterogeneous cancers, often present a challenge for treatment, particularly in the advanced stages. This case series, published in [journal name], investigates the use of temozolomide as a potential treatment option for patients with advanced sarcoma who have failed prior treatment with pazopanib, a vascular endothelial growth factor receptor inhibitor.

The authors present their experience with a small group of patients who received temozolomide after pazopanib treatment failure. While the results are encouraging, suggesting potential activity of temozolomide in this setting, the study emphasizes the need for larger clinical trials to fully assess its efficacy and safety.

Exploring New Treatment Avenues for Advanced Sarcoma

This case series adds to the growing body of research exploring potential treatment options for advanced sarcoma. The authors' findings suggest that temozolomide may have a role in the treatment of this challenging disease.

The Importance of Clinical Trials in Developing New Cancer Therapies

The study highlights the crucial role of clinical trials in evaluating new cancer therapies and developing effective treatment strategies for patients with rare and complex diseases.

Dr.Camel's Conclusion

This case series is a step towards understanding the potential of temozolomide in the treatment of advanced sarcoma. Like a lone traveler seeking a hidden oasis, researchers are exploring new treatments for this rare and often challenging cancer. Further research is needed to confirm its effectiveness and safety, but this study offers a glimmer of hope for patients with advanced sarcoma.

Date :
  1. Date Completed 2017-12-26
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

29141017

DOI: Digital Object Identifier

PMC5687737

Related Literature

SNS
PICO Info
in preparation
Languages

English

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