Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population.

Author: FengYabo, GengHongbin, LiXueqing, LiuYang, LiuYun, WangRutao, WenAidong, ZhangWanzhi, ZhaoNa, ZhengHeng

Paper Details 
Original Abstract of the Article :
Metolazone is a diuretic, saluretic and antihypertensive chemical compound from the quinazoline category that possesses medicinal features similar to those of other thiazide diuretic drugs. However, the pharmacokinetics of metolazone in the Chinese population has rarely been studied. This study aime...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689141/

データ提供:米国国立医学図書館(NLM)

Metolazone: Navigating the Desert of Pharmacokinetics

This research delves into the intricate world of metolazone pharmacokinetics, a field that can be as complex and challenging as navigating a vast desert landscape. The researchers conducted a study to examine the pharmacokinetic characteristics, safety, and tolerability of metolazone in healthy Chinese subjects after single and multiple doses. They explored the effects of food and gender on metolazone's pharmacokinetic parameters to gain a comprehensive understanding of how this medication behaves in the body.

Metolazone: Understanding Its Journey Through the Body

This study provides valuable insights into the pharmacokinetic profile of metolazone in healthy Chinese subjects. The researchers found that metolazone was well-tolerated and exhibited a predictable pharmacokinetic profile. They observed that food intake did not significantly affect metolazone's absorption, but gender did play a role in its elimination. These findings contribute to a better understanding of how metolazone behaves in the body, which can be valuable for optimizing its use in clinical settings.

Medication Management: A Journey of Personalized Care

Understanding how medications behave in the body is crucial for optimizing treatment outcomes. This study provides valuable insights into the pharmacokinetic profile of metolazone, highlighting the importance of considering factors like food intake and gender when prescribing this medication. The researchers found that metolazone was well-tolerated, but it's important to be aware of potential side effects and to monitor patients closely.

Dr.Camel's Conclusion

This study provides a comprehensive analysis of the pharmacokinetic characteristics, safety, and tolerability of metolazone in healthy Chinese subjects. The research sheds light on the influence of food and gender on metolazone's pharmacokinetic profile, offering valuable information for optimizing its use in clinical settings. The findings contribute to a better understanding of how this medication interacts with the body, paving the way for more personalized and effective medication management.

Date :
  1. Date Completed 2018-07-10
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

29145890

DOI: Digital Object Identifier

PMC5689141

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Languages

English

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