Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?

Author: AstileanSimion, BerceCristian, Berindan-NeagoeIoana, BocaSanda, BraicuCornelia, GafencuGrigore-Aristide, JurjAncuta, MicuWilhelm-Thomas, MoisoiuVlad, PetrushevBobe, PopLaura, SeliceanSonia, TemianDaiana, TomuleasaCiprian

Paper Details 
Original Abstract of the Article :
Alopecia is a dermatological condition for which Janus kinase (JAK) inhibitors have recently emerged as potential therapy options, but with limited practical use because of the systemic side effects. The topical use of Ruxolitinib in alopecia universalis has been demonstrated, but little is known ab...See full text at original site
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引用元:
https://doi.org/10.1016/j.mehy.2017.09.023

データ提供:米国国立医学図書館(NLM)

Ruxolitinib-Conjugated Gold Nanoparticles: A New Oasis for Alopecia Treatment

Alopecia, a condition characterized by hair loss, can be a devastating experience for those affected. This study explores the potential of ruxolitinib-conjugated gold nanoparticles (GNPs) as a new topical treatment for alopecia. The authors investigated the efficacy of these nanoparticles in inhibiting fibroblast proliferation, a key mechanism involved in alopecia development.

Gold Nanoparticles: A New Weapon in the Desert of Alopecia

The study found that GNPs conjugated with ruxolitinib effectively inhibited JAK2 protein, leading to reduced fibroblast proliferation. These findings suggest that GNPs may provide a safe and effective topical treatment option for alopecia, minimizing the risk of systemic side effects associated with traditional oral therapies.

Navigating the Desert of Alopecia Treatment

The study highlights the potential of nanomedicine in developing targeted and effective therapies for alopecia. By utilizing GNPs to deliver ruxolitinib directly to the affected area, we can potentially achieve significant therapeutic benefits while minimizing systemic exposure and side effects. Further research is needed to evaluate the long-term efficacy and safety of this innovative treatment approach.

Dr.Camel's Conclusion

The desert of alopecia can be a desolate and isolating place, but with the emergence of new technologies like ruxolitinib-conjugated gold nanoparticles, we can offer a glimmer of hope for those seeking relief from this condition. This study demonstrates the potential of nanomedicine in developing targeted therapies for alopecia, paving the way for a more effective and safe treatment landscape.

Date :
  1. Date Completed 2018-07-13
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

29150291

DOI: Digital Object Identifier

10.1016/j.mehy.2017.09.023

Related Literature

SNS
PICO Info
in preparation
Languages

English

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