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Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model.

Author: BriandFrançois, BrousseauEmmanuel, BurcelinRémy, QuinsatMarjolaine, SulpiceThierry

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Obeticholic acid (OCA) is a drug used to treat nonalcoholic steatohepatitis (NASH), but its dyslipidemic effect in humans cannot be observed in rodent models. This study developed a Diet-Induced NASH (DIN) hamster model to evaluate the impact of OCA. OCA significantly lowered body weight, increased CETP activity and LDL-C levels, reduced HDL-C levels, and reduced fecal bile acids mass excretion in hamsters. The DIN hamster model replicates benefits and side effects of OCA as observed in humans and should be useful for evaluating novel drugs targeting NASH.
Paper Details　
Original Abstract of the Article :
The use of rat and mouse models limits the translation to humans for developing novel drugs targeting nonalcoholic steatohepatitis (NASH). Obeticholic acid (OCA) illustrates this limitation since its dyslipidemic effect in humans cannot be observed in these rodents. Conversely, Golden Syrian hamster...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2017.11.021

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid: A Double-Edged Sword in the Desert of NASH

The world of [nonalcoholic steatohepatitis (NASH)] is a desert of inflammation and metabolic dysfunction. This research investigates the [effects of obeticholic acid (OCA)] in a [Diet-Induced NASH (DIN) hamster model], a model that more closely mimics [human dyslipidemia] than traditional rodent models. The study explored the [impact of OCA] on [lipid metabolism and NASH progression] in the hamsters.

A Complex Landscape of Lipid Metabolism

The study found that [OCA] had [mixed effects] on [lipid profiles] in the hamsters, [raising LDL-cholesterol and reducing HDL-cholesterol]. It's like a desert landscape with shifting sands – OCA can have both positive and negative effects on lipid metabolism, depending on the individual.

Navigating the Desert of NASH Treatment

This research highlights the [complexities] of [NASH treatment] and underscores the importance of [careful consideration] when using [OCA]. It's a reminder that finding the right path through the desert of NASH requires a deep understanding of the condition and its potential treatment options.

Dr.Camel's Conclusion

This research underscores the [importance of using appropriate animal models] in [drug development] to ensure [translation to humans]. It's like choosing the right camel for a desert journey – the right model can lead to more accurate and reliable results.

Date :
  1. Date Completed 2018-07-27
  2. Date Revised 2018-07-27
Further Info :

Pubmed ID

29155143

DOI: Digital Object Identifier

10.1016/j.ejphar.2017.11.021

Related Literature

Article Analysis
・Side Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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