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Thrombin generation estimates the anticoagulation effect of direct oral anticoagulants with significant interindividual variability observed.
Author: HoPrahlad, NandurkarHarshal, NgCheryl, RiganoJoseph
Original Abstract of the Article :
: Direct oral anticoagulants (DOACs) are increasingly being used, primarily due to their drug stability and patient convenience. Although these drugs have been evaluated to be well tolerated in numerous clinical trials, their impact on in-vivo anticoagulation effect, variability and therapeutic drug...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1097/MBC.0000000000000678
データ提供:米国国立医学図書館(NLM)
Direct Oral Anticoagulants: A New Era in Thrombosis Management
Direct oral anticoagulants (DOACs) have revolutionized the treatment of thrombosis, offering greater convenience and efficacy compared to traditional anticoagulants. However, their impact on anticoagulation effect, variability, and therapeutic drug levels remains under investigation. This research examines the effect of DOACs on thrombin generation, a key process in blood clotting.
The authors investigated the effect of dabigatran, rivaroxaban, and apixaban on thrombin generation using a calibrated automated thrombogram. They found that each DOAC had a unique effect on thrombin generation, highlighting the importance of individual patient monitoring and personalized treatment strategies.
Understanding Variability: A Key to Personalized Medicine
This research highlights the significant interindividual variability in the anticoagulation effect of DOACs. It underscores the need for personalized medicine approaches to optimize treatment efficacy and minimize bleeding risk. This research emphasizes the importance of careful monitoring and individualized dosing strategies for patients on DOACs.
Staying Safe: Monitoring and Management
This research underscores the importance of regular monitoring and close collaboration with healthcare professionals for individuals taking DOACs. It emphasizes the need for individualized dosing strategies and careful monitoring to ensure optimal therapeutic benefit while minimizing bleeding risk. This research contributes to the growing body of knowledge about DOACs, paving the way for more personalized and effective anticoagulation therapy.
Dr.Camel's Conclusion
Just as a camel navigates the treacherous desert, managing anticoagulation with DOACs requires a keen understanding of individual variability and careful monitoring. This research emphasizes the importance of personalized medicine approaches to optimize treatment efficacy and ensure patient safety.
Date :
- Date Completed 2018-08-10
- Date Revised 2018-08-10
Further Info :
Related Literature
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