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Determination of lesinurad in rat plasma by a UHPLC-MS/MS assay.

Author: CaiJian-Ping, ChenZhe, HuGuo-Xin, LiXiang-Yu, TangPeng-Fei, YuanLing-Jing, ZhouXiao-Yang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A new, validated method was developed to measure lesinurad, a drug used to treat gout, in rat plasma. The method can be used to study the drug's pharmacokinetics and optimize its use.
Paper Details　
Original Abstract of the Article :
Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with refractory gout. In the present study, a sensitive and speci...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704027/

データ提供：米国国立医学図書館（NLM）

Measuring Lesinurad in Rat Plasma: A New Analytical Tool

Lesinurad, a medication used to treat hyperuricemia associated with gout, has shown promise in clinical settings. This research focuses on developing and validating a sensitive and specific ultra high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) assay for measuring lesinurad in rat plasma. The study provides a detailed description of the assay methodology and its validation parameters. The researchers successfully developed and validated a UHPLC-MS/MS assay for measuring lesinurad in rat plasma, demonstrating its accuracy, precision, and reliability.

A New Oasis in the Desert of Pharmacokinetic Research

This study contributes to the advancement of pharmacokinetic research by providing a validated UHPLC-MS/MS assay for measuring lesinurad in rat plasma. The study's findings offer a valuable tool for researchers studying the pharmacokinetics of lesinurad in animal models, which can ultimately inform clinical research and drug development.

Understanding Drug Action: Essential for Effective Treatment

Understanding the pharmacokinetic properties of medications is crucial for optimizing drug efficacy and minimizing the risk of side effects. This research provides a reliable and sensitive method for measuring lesinurad in rat plasma, advancing our understanding of the drug's pharmacokinetic profile and supporting further research in this area.

Dr. Camel's Conclusion

This research delves into the intricate desert of pharmacokinetic research, providing a new and valuable tool for measuring lesinurad in rat plasma. The study's development and validation of a reliable UHPLC-MS/MS assay offer a significant contribution to the field, paving the way for further research and advancements in drug development and therapy.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

29181594

DOI: Digital Object Identifier

PMC5704027

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Article Analysis
・Effects of lesinurad
SNS
PICO Info
in preparation
Languages

English

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