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Cytotoxic effects of the newly-developed chemotherapeutic agents 17-AAG in combination with oxaliplatin and capecitabine in colorectal cancer cell lines.
Author: AzarbaijaniAnahita Fathi, Khadem AnsariMohammad Hassan, KheradmandFatemeh, MohammadianMahshid, ZeynaliShima
Original Abstract of the Article :
The use of heat shock protein 90 inhibitors like 17-allylamino-17-demethoxy-geldanamycin (17-AAG) has been recently introduced as an attractive anticancer therapy. It has been shown that 17-AAG may potentiate the inhibitory effects of some classical anticolorectal cancer (CRC) agents. In this study,...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691578/
データ提供:米国国立医学図書館(NLM)
Combating Colorectal Cancer: Synergistic Effects of 17-AAG in Combination Therapies
In the ongoing quest to conquer cancer, researchers are constantly seeking innovative treatment strategies. This study investigates the potential of combining 17-AAG, a heat shock protein 90 inhibitor, with existing anti-colorectal cancer (CRC) agents, oxaliplatin and capecitabine. The researchers evaluated the effects of these drugs in various combinations on the proliferation of CRC cell lines. The study's findings reveal synergistic effects when 17-AAG is combined with oxaliplatin or capecitabine, suggesting a potential for enhanced efficacy in treating CRC. However, the study also highlights the importance of further research to optimize the combination therapy and ensure its safety and effectiveness in clinical trials.
A Desert Oasis of Hope: Synergistic Effects in Cancer Treatment
Think of cancer cells as a relentless sandstorm, threatening to engulf the body. This study explores a multi-pronged approach to combating this challenge, combining different anti-cancer agents to create a more effective defense strategy. The study's findings suggest that combining 17-AAG with existing anti-CRC agents can create a synergistic effect, potentially leading to more effective and targeted therapies for colorectal cancer.
A New Weapon in the Fight Against CRC: Synergistic Effects of 17-AAG
This study provides a glimmer of hope in the fight against colorectal cancer. The synergistic effects of 17-AAG in combination therapy offer a potential for more effective treatment strategies. The study's findings underscore the importance of continued research to optimize these combinations, paving the way for new and improved therapies for CRC.
Dr.Camel's Conclusion
This study sheds light on the potential of combining 17-AAG with existing anti-CRC agents to create synergistic effects. Further research is needed to optimize these combinations and validate their safety and efficacy in clinical trials. However, the study's findings offer a promising avenue for developing more effective treatment strategies for colorectal cancer.
Date :
- Date Completed n.d.
- Date Revised 2020-10-01
Further Info :
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