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Brain-targeted intranasal zaleplon solid dispersion in hydrophilic carrier system; 2<sup>3</sup> full-factorial design and in vivo determination of GABA neurotransmitter.

Author: Abd-ElrasheedEman, El-AshmoonyManal M, Nageeb El-HelalySara, SalahSalwa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study aimed to improve the solubility and bioavailability of zaleplon, a medication used to treat insomnia, by developing a solid dispersion formulation. The study found that the new formulation led to a 44% increase in the levels of GABA, a neurotransmitter involved in sleep, in the brain of rabbits compared to the oral tablet formulation.
Paper Details　
Original Abstract of the Article :
Intranasal zaleplon solid dispersion was formulated to enhance the solubility, bioavailability and deliver an effective therapy. Zaleplon belongs to Class II drugs, and undergoes extensive first-pass metabolism after oral absorption exhibiting 30% bioavailability. A 2<sup>3</sup> full-factorial desi...See full text at original site
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引用元：
https://doi.org/10.1080/03639045.2017.1411941

データ提供：米国国立医学図書館（NLM）

Enhancing Drug Delivery to the Brain: A Journey Through the Nasal Passage

Delivering drugs to the brain, a fortress protected by a complex network of barriers, is a challenging task for researchers. This study explores the potential of intranasal zaleplon solid dispersion, a new delivery system, to bypass these barriers, offering a more effective way to deliver this sleep aid to the brain.

Navigating the Barriers to Brain Delivery

The researchers formulated intranasal zaleplon solid dispersion, a novel delivery system akin to building a bridge across a vast desert, to enhance the solubility, bioavailability, and effectiveness of this drug. They utilized a 23 full-factorial design to optimize the formulation, carefully considering various factors like drug to carrier ratio, carrier type, and preparation method.

A New Path to Improved Sleep

The study's findings demonstrate the potential of intranasal zaleplon solid dispersion to enhance the delivery of this sleep aid to the brain, potentially offering a more effective treatment option for insomnia. It's a glimpse into a future where innovative drug delivery systems can overcome the barriers of the brain, providing new pathways to treat a wide range of conditions.

Dr. Camel's Conclusion

This research offers a promising new approach to drug delivery, akin to discovering a hidden oasis in the vast desert of the brain. The potential of intranasal zaleplon solid dispersion to enhance the effectiveness of this sleep aid provides a glimmer of hope for individuals struggling with insomnia. It's a testament to the ongoing quest for better and more efficient ways to deliver medications, a journey that could revolutionize the treatment of various neurological conditions.
Date :
  1. Date Completed 2018-10-01
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29235903

DOI: Digital Object Identifier

10.1080/03639045.2017.1411941

Related Literature

Article Analysis
・Effects of zaleplon
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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