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Posaconazole oral dose and plasma levels in pediatric hematology-oncology patients.

Author: BergerMassimo, CaloreElisabetta, CarraroFrancesca, CesaroSimone, DecembrinoNunzia, MolinaroMariadelfina, PerruccioKatia, PuttiMaria Caterina, RossinSara, TridelloGloria, VicenziEdoardo Bruno

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Posaconazole may be a valuable antifungal agent in children, despite limited pharmacokinetic data.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Posaconazole is a triazole with limited pharmacokinetic information in children. This study assessed the correlation between posaconazole oral solution daily dosage/kg/body weight and trough plasma level. METHODS: A total of 97 hematology-oncology pediatric patients with ≥1 posaconazole...See full text at original site
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引用元：
https://doi.org/10.1111/ejh.13017

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Posaconazole Pharmacokinetics in Pediatric Patients

In the world of pediatric oncology, ensuring the safe and effective use of antifungal medications is paramount. This research explores the pharmacokinetics of posaconazole, a triazole antifungal agent, in hematology-oncology pediatric patients. The authors investigate the correlation between posaconazole dosage and plasma levels, providing valuable insights into optimizing posaconazole treatment in this vulnerable population.

Posaconazole: A Valuable Tool in Pediatric Oncology

This research, much like a desert explorer charting new routes, sheds light on the complexities of posaconazole pharmacokinetics in pediatric patients. The findings suggest that posaconazole can be a valuable antifungal agent in this population, despite the limited pharmacokinetic data. The authors provide guidance on dosage adjustments and identify factors influencing posaconazole plasma levels, paving the way for more effective and personalized treatment strategies.

Optimizing Antifungal Treatment for Children with Cancer

This research, like a well-stocked oasis in the desert, offers valuable resources for healthcare providers treating children with cancer. By understanding the pharmacokinetic characteristics of posaconazole, we can optimize its use in this population, ensuring effective antifungal prophylaxis and treatment while minimizing adverse effects.

Dr.Camel's Conclusion

This research, much like a skilled desert navigator guiding a caravan through treacherous terrain, offers crucial insights into optimizing posaconazole treatment for children with cancer, ensuring their safety and well-being.
Date :
  1. Date Completed 2018-08-14
  2. Date Revised 2018-08-14
Further Info :

Pubmed ID

29240266

DOI: Digital Object Identifier

10.1111/ejh.13017

Related Literature

Article Analysis
・Side Effects of posaconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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