Paper Details 
Original Abstract of the Article :
Tissue plasminogen activator (tPA) thrombolysis remains the gold standard treatment for ischemic stroke. A time-constrained therapeutic window, with the drug to be given within 4.5 h after stroke onset, and lethal side effects associated with delayed treatment, most notably hemorrhagic transformatio...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751355/

データ提供:米国国立医学図書館(NLM)

Expanding the Time Window for Ischemic Stroke Treatment: Adjunctive Therapies

The field of [Neurology] is continuously seeking innovative ways to treat ischemic stroke, a devastating condition that affects millions worldwide. This study explores the potential of adjunctive therapies to expand the time window for tissue plasminogen activator (tPA) thrombolysis, the gold standard treatment for ischemic stroke. The researchers review various pharmacological and non-drug interventions that may mitigate complications and enhance the effectiveness of tPA, paving the way for more effective stroke treatment.

Adjunctive Therapies: A Promising Avenue for Stroke Treatment

This review highlights the limitations of tPA thrombolysis, including a narrow therapeutic window and the risk of hemorrhagic transformation. The authors discuss various pharmacological approaches that can be used in conjunction with tPA to address these limitations. These adjunctive therapies include agents that protect the blood-brain barrier, enhance vascularization, and exert other protective effects. The review also explores non-drug interventions such as stem cell treatments and gas therapy, which have shown promising results in mitigating stroke-related complications and neurological deficits.

Navigating the Shifting Sands of Stroke Treatment

Treating ischemic stroke is like navigating a treacherous desert, where each moment counts. Just as a camel needs to find the right oasis, finding the right treatment strategy is crucial for stroke patients. This review provides a comprehensive overview of adjunctive therapies that can enhance the effectiveness of tPA and expand the therapeutic window for stroke treatment. These advancements in stroke care offer a beacon of hope for individuals facing this debilitating condition.

Dr. Camel's Conclusion

This review presents a compelling case for adjunctive therapies in expanding the time window for ischemic stroke treatment. These innovative approaches hold great promise for improving patient outcomes and mitigating the long-term effects of stroke. As we continue to research and refine these therapies, we can strive to build a more effective sandcastle of stroke treatment, protecting patients from the devastating consequences of this condition.

Date :
  1. Date Completed 2018-07-17
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

29257093

DOI: Digital Object Identifier

PMC5751355

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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