Toxicities, safeties and clinical response of dacarbazine-based chemotherapy on neuroendocrine tumors in Taiwan population.

Author: ChaoYee, ChenMing-Han, ChenMing-Huang, ChienSheng-Hsuan, ChiuHwa-Yen, ChouWen-Chi, FangWen-Liang, HungYi-Ping, LinLiang-Yu, Mu-Hsin ChangPeter, ShyrYi-Ming, YehYi-Chen

Paper Details 
Original Abstract of the Article :
BACKGROUND: Currently, the role of dacarbazine (DTIC) based chemotherapy in neuroendocrine tumors (NETs) in Asia is unclear. Here, we report the outcomes of dacarbazine (DTIC)-based chemotherapy in Taiwan population. METHODS: DTIC alone (250 mg/m RESULTS: 48 patients were reviewed in this study, i...See full text at original site
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引用元:
https://doi.org/10.1016/j.jcma.2017.08.020

データ提供:米国国立医学図書館(NLM)

Dacarbazine-Based Chemotherapy for Neuroendocrine Tumors

This study focuses on the intriguing realm of [oncology] by examining the effectiveness and safety of dacarbazine-based chemotherapy in treating neuroendocrine tumors (NETs) in Taiwan. The authors, driven by the need for better treatment options in this challenging area, conducted a comprehensive investigation using [clinical trial] methods. They carefully documented the treatment outcomes, analyzing factors such as progression-free survival, overall survival, and the presence of side effects. Their findings provide valuable insights into the efficacy of dacarbazine-based therapy in managing NETs, particularly in the Asian population.

Dacarbazine-Based Chemotherapy: A Promising Treatment for NETs

The study reveals that dacarbazine-based chemotherapy exhibits promising results in treating NETs, particularly in patients with grade 3 neuroendocrine carcinomas (NECs) and a Ki-67 index of 20-55%. This finding could be instrumental in guiding future treatment decisions for NET patients. The research also highlights the importance of considering the Ki-67 index as a prognostic factor for grade 3 NEC patients, potentially influencing treatment strategies and outcomes.

Understanding the Potential Benefits and Risks of Dacarbazine-Based Chemotherapy

This study sheds light on the potential benefits of dacarbazine-based chemotherapy in treating NETs, particularly for patients with specific characteristics. However, as with any treatment, potential side effects must be carefully considered. Further research is needed to fully understand the long-term impact of this treatment, and patients should always consult with their healthcare providers to weigh the risks and benefits before making treatment decisions.

Dr.Camel's Conclusion

This research, much like a camel navigating the shifting sands of the desert, explores the effectiveness of dacarbazine-based chemotherapy in treating NETs. It reveals promising results, particularly for patients with certain tumor characteristics, but it also underscores the importance of individual assessment and careful monitoring of potential side effects. This study contributes to a growing body of knowledge in the field of oncology, offering valuable insights into the potential benefits and risks of this chemotherapy approach.

Date :
  1. Date Completed 2019-03-22
  2. Date Revised 2019-03-22
Further Info :

Pubmed ID

29287706

DOI: Digital Object Identifier

10.1016/j.jcma.2017.08.020

Related Literature

SNS
PICO Info
in preparation
Languages

English

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