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Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations.

Author: ChandraJoya, ChengTiewei, DonnellaHayley, IrwinMary E, Rivera-Del ValleNilsa, SinghMelissa M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study evaluated the combined effects of two HDACi with the redox active compound adaphostin in ALL. The study aimed to address the challenge of limited single-agent activity of HDACi in ALL by exploring combinatorial strategies.
Paper Details　
Original Abstract of the Article :
Amongst the epigenetically targeted therapies, targeting of the histone deacetylases (HDACs) has yielded numerous drugs for clinical use in hematological malignancies, but none as yet for acute lymphocytic leukemia (ALL). Single agent activity of HDAC inhibitors (HDACi) has been elusive in ALL, and ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29313067

データ提供：米国国立医学図書館（NLM）

Combinations of HDAC Inhibitors in Acute Lymphoblastic Leukemia

This research ventures into the world of cancer treatment, exploring the potential of histone deacetylase inhibitors (HDACi), a type of drug that targets epigenetic mechanisms involved in cancer development. These drugs offer a promising approach for treating acute lymphoblastic leukemia (ALL), a type of cancer that affects the blood and bone marrow. This study investigates the combinatorial effects of two different HDACi with a redox active compound, adaphostin, in ALL cells.

The researchers found that combining HDACi with adaphostin resulted in distinct redox alterations, suggesting potential synergistic effects in treating ALL. This study provides a foundation for further research into the combinatorial use of HDACi with redox active compounds for the treatment of ALL.

New Approaches to Cancer Treatment

This research explores the potential of combining different types of drugs to effectively target cancer cells. It’s a promising approach that could lead to more effective and personalized cancer therapies. It’s like combining different tools and strategies to conquer a vast and challenging desert landscape.

The Importance of Research in Cancer Care

This research highlights the importance of ongoing research in the field of cancer treatment. It’s a reminder that we must continue to explore new avenues and seek out innovative approaches to conquer this formidable disease.

Dr. Camel’s Conclusion

This study investigates the combinatorial effects of HDACi and adaphostin in ALL cells, suggesting potential synergistic effects in treating this type of cancer. It’s a testament to the ongoing efforts to develop new and effective cancer therapies. This research encourages continued exploration and innovation in the field of cancer research, reminding us that we must never cease our quest for new and effective treatments.
Date :
  1. Date Completed 2019-03-18
  2. Date Revised 2019-03-18
Further Info :

Pubmed ID

29313067

DOI: Digital Object Identifier

NIHMS933186

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Article Analysis
・Effects of vorinostat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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