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Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells.

Author: BarbarinoMarcella, CesariDaniele, CiarciaRoberto, DamianoSara, FlorioSalvatore, GiordanoAntonio, MontagnaroSerena, PagniniUgo, PuzioMaria V, SeverinoLorella

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Resveratrol, rMnSOD and δ-tocotrienol reduced lipid peroxidation induced by Nilotinib (NIL) and Dasatinib (DAS), two tyrosine kinase inhibitors for chronic myeloid leukemia. They also increased intracellular ROS levels, leading to apoptosis.
Paper Details　
Original Abstract of the Article :
In clinical practice for the treatment of chronic myeloid leukemia, second generation of tyrosine kinase inhibitors such as Nilotinib (NIL) specific and potent inhibitor of the BCR/ABL kinase and Dasatinib (DAS) a inhibitor of BCR/ABL and Src family kinase were developed to clinically overcome imati...See full text at original site
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引用元：
https://doi.org/10.1002/jcb.26686

データ提供：米国国立医学図書館（NLM）

Antioxidants and Tyrosine Kinase Inhibitors: A Complex Interaction

Tyrosine kinase inhibitors (TKIs) like nilotinib and dasatinib are essential in the treatment of chronic myeloid leukemia (CML). However, TKIs can induce oxidative stress and apoptosis. This study investigates the effects of various antioxidants on TKI-induced apoptosis in K562 cells. Like a camel seeking shade in a scorching desert, the researchers aimed to understand the interplay between antioxidants and TKIs. They found that certain antioxidants, such as resveratrol, rMnSOD, and δ-tocotrienol, could modulate TKI-induced apoptosis by influencing ROS production and lipid peroxidation. This study provides valuable insights into the potential benefits of using antioxidants in conjunction with TKIs to mitigate their side effects.

Antioxidants: A Potential Protective Mechanism Against TKI-Induced Apoptosis

The study suggests that certain antioxidants may help to protect against TKI-induced apoptosis.

Navigating the Desert of CML Treatment

If you are receiving treatment for CML, it's essential to discuss potential side effects and treatment options with your doctor. They can help you navigate the complexities of CML treatment and optimize your care.

Dr.Camel's Conclusion

This study delves into the intricate relationship between antioxidants and tyrosine kinase inhibitors, highlighting the potential for antioxidants to mitigate the side effects of TKI treatment. It underscores the need for further research to explore the optimal use of antioxidants in CML therapy.

Date :
  1. Date Completed 2019-02-27
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

29345355

DOI: Digital Object Identifier

10.1002/jcb.26686

Related Literature

Article Analysis
・Effects of nilotinib・Effects of dasatinib
SNS
PICO Info
in preparation
Languages

English

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