Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?

Author: Labastida-RamírezAlejandro, MaassenVanDenBrinkAntoinette, Rubio-BeltránEloísa, VillalónCarlos M

Paper Details 
Original Abstract of the Article :
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP). The gold standard for acute migraine treatment are the triptans, 5-HT<sub>1B/1D/(1F)</sub> receptor agonists. Their ac...See full text at original site
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引用元:
https://doi.org/10.1016/j.pharmthera.2018.01.005

データ提供:米国国立医学図書館(NLM)

Ditans: A New Era for Migraine Treatment?

This review explores the potential of ditans, or selective 5-HT1F receptor agonists, as a novel treatment for migraine. It compares and contrasts ditans with triptans, the current gold standard for acute migraine treatment. The authors focus on the specific action of ditans on the [trigeminovascular system] and their [cardiovascular safety] profile.

Ditans: Navigating the Complexities of Migraine Treatment

This research delves into the [fascinating world] of [migraine treatment] and explores the potential of ditans as a new therapeutic approach. The authors highlight the [unique characteristics] of ditans, such as their selectivity for the 5-HT1F receptor and their [favorable cardiovascular profile]. Ditans might offer a safer and more effective treatment option for migraine sufferers, particularly those with cardiovascular concerns.

Addressing the [Individualized Needs] of Migraine Sufferers

Migraine is a complex condition, and finding the [right treatment] can be a journey. This research sheds light on the [potential] of ditans, a new class of migraine medications, to offer a [more targeted approach] to treatment. By understanding the specific actions of ditans and their potential benefits, individuals can work with their healthcare providers to [make informed decisions] about their migraine management.

Dr. Camel's Conclusion

The search for effective and safe migraine treatments continues. This review highlights the [promise] of ditans, selective 5-HT1F receptor agonists. Ditans may offer a new way to [tackle migraine] while minimizing the cardiovascular risks associated with traditional triptans. Just as a [camel's call] resonates across the vast desert, ditans could offer a [clearer path] for individuals seeking relief from migraine symptoms.
Date :
  1. Date Completed 2019-02-04
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

29352859

DOI: Digital Object Identifier

10.1016/j.pharmthera.2018.01.005

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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