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Statins differentially modulate microRNAs expression in peripheral cells of hyperlipidemic subjects: A pilot study.

Author: CerdaÁlvaro, HirataMario H, HirataRosario D C, SalazarLuis A, ZambranoTomás

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

While statins are a key treatment for high cholesterol, some people don't respond well to them. The reasons for this are unclear, but recent research suggests that small molecules called miRNAs may play a role. This study aims to investigate how short-term, low-dose treatment with two statins affects miRNA levels in patients with high cholesterol.
Paper Details　
Original Abstract of the Article :
Although statins are considered a cornerstone for the treatment of high cholesterol levels due to their powerful cholesterol-lowering effects, response to drug administration is still one of the main pitfalls of statin treatment. So far, the reasons underlying this undesired outcome are still poorly...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2018.02.007

データ提供：米国国立医学図書館（NLM）

Statins: Understanding the Variability in Cholesterol-Lowering Effects

Statins are a cornerstone of cholesterol management, but their effectiveness can vary significantly between individuals. This study delves into the potential role of microRNAs (miRNAs) in explaining these differences in response to statin treatment. The researchers investigated the effects of two different statins on miRNA expression in patients with high cholesterol. The findings suggest that statins can influence the expression of specific miRNAs, potentially contributing to variations in cholesterol-lowering effects. It's like uncovering a new layer of complexity in the desert of cholesterol management, shedding light on the intricate interplay between medications and our genetic makeup.

Unraveling the Mystery of Statin Variability

This study offers valuable insights into the complex mechanisms underlying statin response. The researchers' findings highlight the potential role of miRNAs in modulating cholesterol levels and suggest that personalized approaches to statin therapy might be more effective. It's like finding a new tool for navigating the desert of cholesterol management, allowing for more precise and targeted strategies.

The Importance of Personalized Cholesterol Management

This research further underscores the importance of personalized medicine in cholesterol management. Understanding the unique genetic and molecular factors that influence statin response can lead to more effective and tailored treatment strategies. It's like choosing the right path in the desert, one that is specifically tailored to the individual's needs and journey.

Dr. Camel's Conclusion

The desert of cholesterol management is full of hidden complexities. This study reveals the potential role of miRNAs in influencing statin response, reminding us that a deeper understanding of individual variations is crucial for optimal treatment outcomes. It's like discovering a new oasis in the desert, a place where we can explore the intricate mechanisms of statin therapy and develop more effective and personalized approaches to managing cholesterol.

Date :
  1. Date Completed 2018-10-02
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29427701

DOI: Digital Object Identifier

10.1016/j.ejps.2018.02.007

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

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