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Use of the hepatitis B recombinant DNA yeast vaccine (H-B-VAX II) in children: two doses vs. three doses of 5 micrograms regime; an interim report.

Author: ChangW K, LaiC L, LoV W, NgL N, YeohE K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hepatitis B vaccine (H-B-VAX II) was safe and effective in children. 96-100% of vaccinees had an anti-HBs response. Fever was the most common side effect.
Paper Details　
Original Abstract of the Article :
In a prospective randomised trial, children of hepatitis B carriers who were 3 months to 11 years of age and negative for all hepatitis B viral markers were randomised to receive (a) two doses of 5 micrograms of hepatitis B recombinant DNA yeast vaccine (H-B-VAX II) at 0 and 1 month (Group I), (b) t...See full text at original site
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引用元：
https://doi.org/10.1016/s0163-4453(86)92623-x

データ提供：米国国立医学図書館（NLM）

Hepatitis B Vaccination in Children: Two vs. Three Doses

Hepatitis B is a serious viral infection that can cause liver disease. Vaccination is a vital tool for preventing hepatitis B infection. This study compared the effectiveness of two different vaccination regimens for children of hepatitis B carriers: a two-dose regimen and a three-dose regimen.

The study found that both the two-dose and three-dose regimens of the hepatitis B recombinant DNA yeast vaccine (H-B-VAX II) were safe and effective in inducing an immune response in children. While the three-dose regimen resulted in higher antibody titers, both regimens provided significant protection against hepatitis B infection.

Protecting Children from Hepatitis B

The study highlights the effectiveness of hepatitis B vaccination in children, confirming its safety and efficacy in preventing infection. The findings provide valuable information for healthcare providers when making vaccination recommendations.

The Importance of Vaccination

Hepatitis B vaccination is a crucial step in protecting children from this serious infection. Consult with your child's healthcare provider to ensure they receive the appropriate vaccination schedule.

Dr.Camel's Conclusion

Just like a camel navigating a desert filled with potential threats, protecting children from infectious diseases is a top priority. This study, like a well-stocked caravan offering vital supplies, demonstrates the effectiveness of hepatitis B vaccination, reminding us that vaccination is essential for safeguarding children's health.

Date :
  1. Date Completed 1986-10-10
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

2943812

DOI: Digital Object Identifier

10.1016/s0163-4453(86)92623-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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