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A multicentred phase III comparative clinical trial of depot-medroxyprogesterone acetate given three-monthly at doses of 100 mg or 150 mg: 1. Contraceptive efficacy and side effects. World Health Organization Task Force on Long-Acting Systemic Agents for Fertility Regulation. Special Programme of Research, Development and Research Training in Human Reproduction.

Author: AjmalF, BenitezI B, KaziA, KiriwatO, KoetsawangS, OmarK, Pretnar-DarovecA, SaidS, SrisatayapanY, WynterH H

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two doses of depot-medroxyprogesterone acetate (DMPA), 100 mg and 150 mg, were compared for efficacy and side effects in women. Both doses showed comparable results in terms of effectiveness and continuation rates. The discontinuation rate was higher for amenorrhea in the 150mg group. No significant difference in other side effects was observed between the two doses.
Paper Details　
Original Abstract of the Article :
Two dosages of depot-medroxyprogesterone acetate (DMPA), 100 mg and 150 mg given every 90 days, were compared in two groups of women with regard to effectiveness, reported complaints and reasons for discontinuation. A total of 1216 women were recruited into a seven-centre, multinational, randomized ...See full text at original site
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引用元：
https://doi.org/10.1016/0010-7824(86)90004-1

データ提供：米国国立医学図書館（NLM）

Depot-Medroxyprogesterone Acetate: A Contraceptive Option

Contraception is a crucial aspect of reproductive health, and depot-medroxyprogesterone acetate (DMPA) is a long-acting hormonal contraceptive option. This multicenter clinical trial investigates the efficacy and side effects of two dosages of DMPA, 100mg and 150mg, administered every 90 days. Imagine researchers conducting a clinical trial, carefully examining the effects of different doses of a medication on a group of volunteers, like a team of scientists meticulously mapping the effects of a new irrigation system on different parts of a desert ecosystem.

DMPA: A Contraceptive Success Story

The results of the study demonstrate the effectiveness of both dosages of DMPA in preventing pregnancy. The study also found that the two dosages had similar side effect profiles. It's like testing two different types of watering techniques in the desert – both effective in sustaining life, but each with its own unique characteristics. This study provides valuable information for healthcare providers and individuals seeking an effective and long-acting contraceptive option.

Navigating the Desert of Contraception

DMPA is a valuable contraceptive tool, but it's important to be aware of its potential side effects, as with any medication. This study emphasizes the importance of understanding the benefits and risks of different contraceptive options. It's like choosing the right route through a desert – some paths are smoother and more comfortable, while others require more careful consideration. This study provides vital information for choosing the right contraceptive option to meet individual needs and preferences.

Dr. Camel's Conclusion

This clinical trial sheds light on the effectiveness and safety of DMPA as a contraceptive method. It's like exploring a new oasis in the desert of contraception, revealing its benefits and limitations. This study underscores the importance of informed decision-making when it comes to reproductive health and the need for careful consideration of individual needs and preferences.

Date :
  1. Date Completed 1987-02-10
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2947777

DOI: Digital Object Identifier

10.1016/0010-7824(86)90004-1

Related Literature

Article Analysis
・Side Effects of medroxyprogesterone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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