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SGLT-2 inhibitors and the risk of infections: a systematic review and meta-analysis of randomized controlled trials.

Author: AzoulayLaurent, FilionKristian B, PuckrinRobert, ReynierPauline, SaltielMarie-Philippe, YuOriana H Y

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are associated with an increased risk of genital tract infections, particularly with higher doses of dapagliflozin.
Paper Details　
Original Abstract of the Article :
AIMS: There is concern about the infection-related safety profile of sodium-glucose co-transporter 2 (SGLT-2) inhibitors. We aimed to determine the effect of SGLT-2 inhibitors on genitourinary and other infections via systematic review and meta-analysis of randomized controlled trials (RCTs). METHO...See full text at original site
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引用元：
https://doi.org/10.1007/s00592-018-1116-0

データ提供：米国国立医学図書館（NLM）

SGLT-2 Inhibitors: Navigating the Complex Landscape of Infections

This research delves into the growing concern regarding the [infection-related safety profile] of [sodium-glucose co-transporter 2 (SGLT-2) inhibitors]. The study conducted a [systematic review and meta-analysis of randomized controlled trials] to assess the impact of [SGLT-2 inhibitors] on [genitourinary and other infections] in patients with [type 2 diabetes]. The researchers analyzed data from [86 RCTs enrolling 50,880 patients] to determine the overall risk associated with these medications.

The Complexities of SGLT-2 Inhibitors and Infections

The study's findings offer a nuanced perspective on the potential risks associated with [SGLT-2 inhibitors]. While [SGLT-2 inhibitors] were found to [increase the risk of genital infections] compared to [placebo], there was [no overall association between SGLT-2 inhibitors and UTI]. However, [higher doses of dapagliflozin] were associated with an [increased risk of UTI], highlighting the importance of careful dose selection and patient monitoring.

Navigating the Desert of Diabetes with SGLT-2 Inhibitors

This research is like navigating a complex desert landscape, exploring the potential benefits and risks associated with [SGLT-2 inhibitors] in the management of [type 2 diabetes]. The study's findings underscore the importance of a cautious approach, recognizing that these medications may increase the risk of certain [infections], particularly at higher doses. These insights can help guide clinicians in making informed decisions about treatment strategies.

Dr.Camel's Conclusion

This research is like a journey through a desert of data, exploring the complex relationship between [SGLT-2 inhibitors] and [infections]. The study's findings underscore the need for careful consideration and ongoing monitoring when using these medications, reminding us that even in the desert of medicine, there are hidden dangers that require careful navigation.

Date :
  1. Date Completed 2018-06-12
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

29484489

DOI: Digital Object Identifier

10.1007/s00592-018-1116-0

Related Literature

Article Analysis
・Side Effects of dapagliflozin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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