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Comparative Efficacy of Treatments for Previously Treated Multiple Myeloma: A Systematic Literature Review and Network Meta-analysis.

Author: AhdesmäkiOuti, AinsworthClaire, BellJudith, HaweEmma, Le MoineJean-Gabriel, MaieseEric M

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic literature review and network meta-analysis (NMA) estimated the relative efficacy of treatments for previously treated patients with multiple myeloma (MM), examining the most efficacious therapy among newly approved therapies like daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd).
Paper Details　
Original Abstract of the Article :
New therapies, including daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd), have recently been approved in the United States for patients with multiple myeloma (MM) who have received at least 1 prior line of therapy. However, few treatmen...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.clinthera.2018.01.014

データ提供：米国国立医学図書館（NLM）

Multiple Myeloma: A Search for Effective Treatment

Cancer treatment is a journey through a complex and ever-evolving landscape. This systematic literature review and network meta-analysis (NMA) investigates the efficacy of various treatment options for patients with multiple myeloma (MM), a type of blood cancer. The authors sought to clarify the relative effectiveness of different therapies, navigating through a vast desert of clinical trials and research findings. The study focused on treatments for patients who have already received at least one prior line of therapy, highlighting the need for new and effective treatment options for those with recurrent or refractory MM.

New Hope for Multiple Myeloma Patients

The review identified promising results with two new therapies: daratumumab plus lenalidomide plus dexamethasone (DRd) and daratumumab plus bortezomib plus dexamethasone (DVd). These treatments showed significant improvements in progression-free survival (PFS), a key metric in cancer treatment. The results are like a refreshing oasis in the desert of myeloma treatment, offering new hope for patients facing challenging situations.

Navigating the Treatment Options

The NMA provides a comprehensive overview of the relative efficacy of various therapies for multiple myeloma. This information is crucial for oncologists as they navigate treatment decisions with their patients. It's like having a map of the treatment desert, guiding them towards the most effective and personalized care. This research is a testament to the ongoing efforts to find better treatments for patients with multiple myeloma, a relentless pursuit in the desert of cancer research.

Dr. Camel's Conclusion

This study illuminates the ever-expanding landscape of multiple myeloma treatment. It highlights the need for personalized care and provides valuable insights into the effectiveness of different therapies. The authors, like skilled desert explorers, have meticulously mapped the terrain of myeloma treatment, offering crucial information to guide clinicians and provide hope to patients. This research is a testament to the enduring quest for better cancer treatments, a journey that continues to illuminate the desert of medical knowledge.

Date :
  1. Date Completed 2019-03-05
  2. Date Revised 2019-03-05
Further Info :

Pubmed ID

29500140

DOI: Digital Object Identifier

10.1016/j.clinthera.2018.01.014

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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