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Metabolomics Based Profiling of Dexamethasone Side Effects in Rats.
Author: Abdel RahmanAnas M, Al FarajAchraf, AliAsmaa, AlmuhannaFalah, AlzoubiKarem H, DasoukiMajed, JacobMinnie, MalkawiAbeer K, MaticGoran
Original Abstract of the Article :
Dexamethasone (Dex) is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressant effects and is used in several conditions such as asthma and severe allergy. Patients receiving Dex, either at a high dose or for a long time, might develop several side effects such as hyperglycemia, ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820529/
データ提供：米国国立医学図書館（NLM）
Unveiling the Metabolic Landscape of Dexamethasone Side Effects
Dexamethasone, a potent steroid medication, is widely used for its anti-inflammatory and immunosuppressive properties. This study investigates the metabolic side effects of dexamethasone treatment in rats, using a comprehensive metabolomic profiling approach. The researchers analyzed changes in serum metabolites in rats treated with dexamethasone, identifying specific metabolic pathways affected by the drug. This study offers valuable insights into the metabolic consequences of dexamethasone therapy, highlighting the importance of understanding drug-induced metabolic alterations.
Navigating the Desert of Drug Side Effects: A Metabolomic Approach
The study reveals that dexamethasone treatment can lead to significant metabolic changes, affecting amino acid metabolism, glucose metabolism, and lipid metabolism. This finding underscores the importance of considering metabolic consequences when prescribing dexamethasone, particularly for long-term or high-dose therapy. It's a reminder that navigating the desert of drug side effects requires a comprehensive understanding of the intricate interplay between medications and metabolism.
Living with Medications: A Journey of Awareness and Personalized Care
Medications are essential for treating various illnesses, but they can also have unintended consequences. This study highlights the importance of being aware of potential metabolic side effects and working with healthcare providers to manage these risks. It encourages us to embrace personalized medicine, tailoring treatment plans to individual needs and minimizing the potential for adverse effects. It's a reminder that the journey through the desert of medication use requires vigilance, open communication, and a commitment to personalized care.
Dr.Camel's Conclusion
This study underscores the importance of considering the metabolic consequences of dexamethasone treatment. It's a reminder that understanding the intricate interplay between medications and metabolism is crucial for ensuring patient safety and optimizing treatment outcomes. It's a journey through the desert of drug metabolism, where careful navigation and personalized care are essential for maintaining health and well-being.
Date :
- Date Completed n.d.
- Date Revised 2022-03-31
Further Info :
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