Paper Details

  1. Home
  2. Paper Details

Long-term treatment of tumor-operated mice with high doses of alpha-difluoromethylornithine.

Author: AlgranatiI D, FuchsA, KleinS, de LustigE S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Alpha-difluoromethylornithine, a polyamine synthesis inhibitor, demonstrated a significant reduction in lung metastases in mice with mammary adenocarcinoma. However, it also caused side effects like weight loss, delayed wound healing, and a decrease in megakaryocytes.
Paper Details　
Original Abstract of the Article :
Mice inoculated subcutaneously with a mammary adenocarcinoma M3cell suspension and submitted 10 to 15 days later to the surgical removal of primary tumors have been chosen in our laboratory as the experimental model to study the effect of several drugs on metastasis spreading. A 90-day treatment of ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1768-322x.1986.tb00510.x

データ提供：米国国立医学図書館（NLM）

Long-term treatment of tumor-operated mice with high doses of alpha-difluoromethylornithine.

This study delves into the effects of long-term treatment with alpha-difluoromethylornithine, a drug known to inhibit polyamine synthesis, in mice with surgically removed mammary adenocarcinomas. This research is like observing a colony of desert ants after a fire, investigating how they adapt and rebuild their colony over time.

What Does This Research Suggest?

This research suggests that long-term treatment with high doses of alpha-difluoromethylornithine can significantly reduce the number of lung metastases in tumor-operated mice. While the drug demonstrates potential benefits, it also comes with significant side effects. It's like finding a potent desert herb that can cure a specific ailment but also has unintended consequences if not used carefully.

Implications for Your Health and Lifestyle

This research provides insights into the potential benefits and risks of using alpha-difluoromethylornithine for cancer treatment. It underscores the importance of carefully weighing the potential benefits against the potential side effects of any medication. It's like carefully navigating the desert, acknowledging both the beauty and the dangers that lie ahead.

Dr. Camel's Conclusion

This study highlights the complex nature of cancer treatment and the importance of carefully considering all aspects of drug therapy. It's like navigating a treacherous desert, where careful planning and a deep understanding of the environment are essential for success.

Date :
  1. Date Completed 1987-06-08
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

2952208

DOI: Digital Object Identifier

10.1111/j.1768-322x.1986.tb00510.x

Related Literature

Article Analysis
・Side Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.